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Strap Gene Detail
Summary
  • Symbol
    Strap
  • Name
    serine/threonine kinase receptor associated protein
  • Synonyms
    C78091, Unrip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329037
    NCBI Gene: 20901
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:137712080-137728928 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 67.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329037
 protein coding gene Chr6:137712076-137728930 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031437
 protein coding gene Chr6:142298416-142315390 (+)
A/J MGP_AJ_G0031412
 protein coding gene Chr6:136684869-136701696 (+)
AKR/J MGP_AKRJ_G0031340
 protein coding gene Chr6:140838051-140859414 (+)
BALB/cJ MGP_BALBcJ_G0031419
 protein coding gene Chr6:136531288-136548547 (+)
C3H/HeJ MGP_C3HHeJ_G0031141
 protein coding gene Chr6:140854828-140872097 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031881
 protein coding gene Chr6:146135448-146152219 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029010
 protein coding gene Chr6:135727845-135744825 (+)
CAST/EiJ MGP_CASTEiJ_G0030509
 protein coding gene Chr6:140350190-140367223 (+)
CBA/J MGP_CBAJ_G0031101
 protein coding gene Chr6:151697433-151717831 (+)
DBA/2J MGP_DBA2J_G0031258
 protein coding gene Chr6:135541060-135557737 (+)
FVB/NJ MGP_FVBNJ_G0031209
 protein coding gene Chr6:134414444-134431080 (+)
LP/J MGP_LPJ_G0031342
 protein coding gene Chr6:142419540-142436781 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031249
 protein coding gene Chr6:155517563-155537640 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031913
 protein coding gene Chr6:140573937-140591599 (+)
PWK/PhJ MGP_PWKPhJ_G0030236
 protein coding gene Chr6:134017375-134034293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030060
 protein coding gene Chr6:138815560-138834154 (+)
WSB/EiJ MGP_WSBEiJ_G0030602
 protein coding gene Chr6:141214779-141233214 (+)



Homology
more
  • Human Ortholog
    STRAP, serine/threonine kinase receptor associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRAP, serine/threonine kinase receptor associated protein
  • Synonyms
    MAWD, PT-WD, UNRIP
  • Links
    NCBI Gene ID: 11171
    neXtProt AC: NX_Q9Y3F4
    UniProt: Q9Y3F4

  • Chr Location
    12p12.3; chr12:15882387-15903478 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human STRAP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die between E10.5 and E12.5 displaying defects in angiogenesis, cardiogenesis, somitogenesis, neural tube closure and embryonic turning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    977
  • Tissues
    98
  • cDNA Data
    187
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20901 NCBI Gene Model | MGI Sequence Detail 16849 C57BL/6J ±  kb
transcript NM_011499 RefSeq | MGI Sequence Detail 2644 C57BL/6  
polypeptide Q9Z1Z2 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003203 serine-threonine kinase receptor-associated protein
    (term hierarchy)
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q9Z1Z2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 188
    cDNA 187
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1353565, MGI:2141711, MGI:2141747
References
more
  • Summaries
    All 50
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:51613 Datta PK, et al., Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 1998 Dec 25;273(52):34671-4
  • Latest
    J:332942 Vu T, et al., Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. Gastroenterology. 2022 Jan;162(1):193-208
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory