Krtap6-1 Gene Detail

Summary

• Symbol
  Krtap6-1
• Name
  keratin associated protein 6-1

• Feature Type
  protein coding gene
• IDs
  MGI:1330228
  NCBI Gene: 16700
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr16:88828587-88829180 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, 51.42 cM, cytoband C3.3
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  125 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330228	protein coding gene	Chr16:88828587-88829180 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023007	protein coding gene	Chr16:89857225-89857812 (+)
A/J	MGP_AJ_G0022975	protein coding gene	Chr16:85690196-85690789 (+)
AKR/J	MGP_AKRJ_G0022945	protein coding gene	Chr16:88305459-88306046 (+)
BALB/cJ	MGP_BALBcJ_G0022977	protein coding gene	Chr16:86225049-86225642 (+)
C3H/HeJ	MGP_C3HHeJ_G0022738	protein coding gene	Chr16:88860853-88861440 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023424	protein coding gene	Chr16:92750756-92751352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020928	protein coding gene	Chr16:83495460-83496006 (+)
CAST/EiJ	MGP_CASTEiJ_G0022258	protein coding gene	Chr16:89314517-89315021 (+)
CBA/J	MGP_CBAJ_G0022707	protein coding gene	Chr16:96704184-96704771 (+)
DBA/2J	MGP_DBA2J_G0022841	protein coding gene	Chr16:85624523-85625110 (+)
FVB/NJ	MGP_FVBNJ_G0022816	protein coding gene	Chr16:84720050-84720643 (+)
LP/J	MGP_LPJ_G0022911	protein coding gene	Chr16:89545835-89546422 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022836	protein coding gene	Chr16:101307533-101308126 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023442	protein coding gene	Chr16:88792000-88792571 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0021834	protein coding gene	Chr16:88353065-88353658 (+)
WSB/EiJ	MGP_WSBEiJ_G0022309	protein coding gene	Chr16:89032442-89033388 (+)

Homology

• Human Ortholog
  KRTAP6-3, keratin associated protein 6-3

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP6-3, keratin associated protein 6-3
  
• Synonyms
  KAP6.3
• Links
  HGNC:18933

  NCBI Gene ID: 337968

  UniProt: Q3LI67

  
  
• Chr Location
  21q22.11; chr21:30592440-30593075 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap6-1 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: KRTAP6-3
• Gene Tree
  Krtap6-1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  3
• Targeted
  2
• Genomic Mutations
  3 involving Krtap6-1
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  13

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS37389.1

• Ensembl
  ENSMUSG00000058172 (Evidence)
• NCBI Gene
  16700

Representative Sequences			Length	Strain/Species
genomic	16700	NCBI Gene Model | MGI Sequence Detail	594	C57BL/6J
transcript	NM_010672	RefSeq | MGI Sequence Detail	594	C57BL/6
polypeptide	NP_034802	RefSeq | MGI Sequence Detail	78	C57BL/6

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR040313 Keratin-associated protein 6

Molecular
Reagents

• All nucleic 17

  cDNA 17

  
  

  Microarray probesets 4

References

• Summaries
  All 27

  Phenotypes 8
• Earliest
  J:44334 Aoki N, et al., Isolation and characterization of mouse high-glycine/tyrosine proteins. J Biol Chem. 1997 Nov 28;272(48):30512-8
• Latest
  J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077