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Dpm2 Gene Detail
Summary
  • Symbol
    Dpm2
  • Name
    dolichyl-phosphate mannosyltransferase subunit 2, regulatory
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330238
    NCBI Gene: 13481
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32460870-32463583 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330238
 protein coding gene Chr2:32460870-32463591 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025610
 protein coding gene Chr2:31045302-31048023 (+)
A/J MGP_AJ_G0025587
 protein coding gene Chr2:29718199-29720908 (+)
AKR/J MGP_AKRJ_G0025557
 protein coding gene Chr2:30783272-30785981 (+)
BALB/cJ MGP_BALBcJ_G0025584
 protein coding gene Chr2:29843579-29846300 (+)
C3H/HeJ MGP_C3HHeJ_G0025344
 protein coding gene Chr2:30672951-30675672 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026028
 protein coding gene Chr2:31985992-31988711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023437
 protein coding gene Chr2:28438158-28440873 (+)
CAST/EiJ MGP_CASTEiJ_G0024806
 protein coding gene Chr2:30612108-30614817 (+)
CBA/J MGP_CBAJ_G0025322
 protein coding gene Chr2:33203274-33205995 (+)
DBA/2J MGP_DBA2J_G0025455
 protein coding gene Chr2:29486496-29489205 (+)
FVB/NJ MGP_FVBNJ_G0025417
 protein coding gene Chr2:29361505-29364214 (+)
LP/J MGP_LPJ_G0025541
 protein coding gene Chr2:30921071-30923792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025448
 protein coding gene Chr2:32836199-32838908 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026086
 protein coding gene Chr2:30661895-30664604 (+)
PWK/PhJ MGP_PWKPhJ_G0024554
 protein coding gene Chr2:29391632-29394311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024354
 protein coding gene Chr2:30816631-30819339 (+)
WSB/EiJ MGP_WSBEiJ_G0024875
 protein coding gene Chr2:30838255-30840964 (+)



Homology
more
  • Human Ortholog
    DPM2, dolichyl-phosphate mannosyltransferase subunit 2, regulatory
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPM2, dolichyl-phosphate mannosyltransferase subunit 2, regulatory
  • Synonyms
    CDG1U
  • Links
    NCBI Gene ID: 8818
    neXtProt AC: NX_O94777
    UniProt: O94777

  • Chr Location
    9q34.11; chr9:127935099-127937854 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    131
  • cDNA Data
    79
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13481 NCBI Gene Model | MGI Sequence Detail 2714 C57BL/6J ±  kb
    transcript NM_010073 RefSeq | MGI Sequence Detail 877 Not Specified  
    polypeptide Q9Z324 UniProt | EBI | MGI Sequence Detail 84 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006657 dolichol phosphate-mannose biosynthesis regulatory protein
      (term hierarchy)
    • InterPro Domains
      IPR009914 Dolichol phosphate-mannose biosynthesis regulatory
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139402, MGI:2139545
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:50812 Maeda Y, et al., DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. EMBO J. 1998 Sep 1;17(17):4920-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory