Ptgdr2 MGI Mouse Gene Detail - MGI:1330275 - prostaglandin D2 receptor 2

Symbol

Ptgdr2
Name

prostaglandin D2 receptor 2
Synonyms

Crth2, Gpr44, PGD2 receptor

Feature Type

protein coding gene
IDs

MGI:1330275
NCBI Gene: 14764
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:10914524-10919875 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 7.40 cM
Mapping Data

1 experiment

SNPs within 2kb

266 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330275	protein coding gene	Chr19:10901883-10919875 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024863	protein coding gene	Chr19:8319602-8324932 (+)
A/J	MGP_AJ_G0024831	protein coding gene	Chr19:7754688-7762443 (+)
AKR/J	MGP_AKRJ_G0024806	protein coding gene	Chr19:8056978-8062310 (+)
BALB/cJ	MGP_BALBcJ_G0024831	protein coding gene	Chr19:7799536-7804865 (+)
C3H/HeJ	MGP_C3HHeJ_G0024597	protein coding gene	Chr19:7947579-7952864 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025279	protein coding gene	Chr19:8673421-8678729 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022706	protein coding gene	Chr19:8171911-8177186 (+)
CAST/EiJ	MGP_CASTEiJ_G0024070	protein coding gene	Chr19:7604220-7609463 (+)
CBA/J	MGP_CBAJ_G0024571	protein coding gene	Chr19:8737231-8744855 (+)
DBA/2J	MGP_DBA2J_G0024698	protein coding gene	Chr19:7759769-7765076 (+)
FVB/NJ	MGP_FVBNJ_G0024665	protein coding gene	Chr19:7805631-7811696 (+)
LP/J	MGP_LPJ_G0024785	protein coding gene	Chr19:8273297-8278578 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024692	protein coding gene	Chr19:8624766-8631813 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025327	protein coding gene	Chr19:8078211-8083490 (+)
PWK/PhJ	MGP_PWKPhJ_G0023815	protein coding gene	Chr19:7214126-7219429 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023620	protein coding gene	Chr19:7266168-7271840 (+)
WSB/EiJ	MGP_WSBEiJ_G0024132	protein coding gene	Chr19:7972343-7978654 (+)

Human Ortholog

PTGDR2, prostaglandin D2 receptor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGDR2, prostaglandin D2 receptor 2
Synonyms

CD294, CRTH2, DL1R, DP2, GPR44
Links

HGNC:4502

NCBI Gene ID: 11251

neXtProt AC: NX_Q9Y5Y4

UniProt: Q9Y5Y4
Chr Location

11q12.2; chr11:60850933-60855950 (-) GRCh38

MGI Vertebrate Homology

Ptgdr2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTGDR2
Gene Tree

Ptgdr2

Diseases

1 with human PTGDR2 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 3 alleles in 5 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show enhanced IL-5 production and eosinophil recruitment into the lung in an allergic airway inflammatory model. In contrast, mice homozygous for a second knock-out allele exhibit lower serum IgE levels and reduced IgE-mediated inflammatory responses in skin.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

49
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

8
UniProt

1
CCDS

CCDS29592.1

Ensembl

ENSMUSG00000034117 (Evidence)
NCBI Gene

14764

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034117	Ensembl Gene Model \| MGI Sequence Detail	5352	C57BL/6J	± kb
transcript	ENSMUST00000037261	Ensembl \| MGI Sequence Detail	2644	Not Applicable
polypeptide	ENSMUSP00000036159	Ensembl \| MGI Sequence Detail	382	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001547 prostaglandin D2 receptor DP2

(term hierarchy)
InterPro Domains

IPR000826 Formyl peptide receptor-related

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q9Z2J6 3 sites

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 3

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MGI:1336994

Summaries

All 63

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 32
Earliest

J:49129 Mayer H, et al., Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor. Biochim Biophys Acta. 1998 Jul 30;1399(1):51-6
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Ptgdr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155148	Chr19:10914518-10914542 (+)	6 bp
Tssr155149	Chr19:10915115-10915123 (+)	595 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24