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Hyal3 Gene Detail
Summary
  • Symbol
    Hyal3
  • Name
    hyaluronoglucosaminidase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330288
    NCBI Gene: 109685
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107458495-107464558 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330288
 protein coding gene Chr9:107458017-107464558 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035262
 protein coding gene Chr9:109461393-109472162 (+)
A/J MGP_AJ_G0035241
 protein coding gene Chr9:105477830-105484228 (+)
AKR/J MGP_AKRJ_G0035173
 protein coding gene Chr9:108111486-108117955 (+)
BALB/cJ MGP_BALBcJ_G0035235
 protein coding gene Chr9:105147103-105153681 (+)
C3H/HeJ MGP_C3HHeJ_G0034945
 protein coding gene Chr9:108509127-108515564 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035755
 protein coding gene Chr9:112447790-112454340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032653
 protein coding gene Chr9:102907314-102913892 (+)
CAST/EiJ MGP_CASTEiJ_G0034256
 protein coding gene Chr9:108441732-108450034 (+)
CBA/J MGP_CBAJ_G0034913
 protein coding gene Chr9:116421686-116428193 (+)
DBA/2J MGP_DBA2J_G0035074
 protein coding gene Chr9:104931503-104938028 (+)
FVB/NJ MGP_FVBNJ_G0035022
 protein coding gene Chr9:103696903-103703918 (+)
LP/J MGP_LPJ_G0035150
 protein coding gene Chr9:109662498-109669935 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035061
 protein coding gene Chr9:118033955-118041480 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035776
 protein coding gene Chr9:108383099-108391996 (+)
PWK/PhJ MGP_PWKPhJ_G0033963
 protein coding gene Chr9:105252016-105258646 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033798
 protein coding gene Chr9:108437319-108443605 (+)
WSB/EiJ MGP_WSBEiJ_G0034377
 protein coding gene Chr9:108264382-108271839 (+)



Homology
more
  • Human Ortholog
    HYAL3, hyaluronidase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYAL3, hyaluronidase 3
  • Synonyms
    HYAL-3, LUCA-3, LUCA3
  • Links
    NCBI Gene ID: 8372
    neXtProt AC: NX_O43820
    UniProt: O43820

  • Chr Location
    3p21.31; chr3:50292831-50299405 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in a mild lung phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    101
  • cDNA Data
    6
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109685 NCBI Gene Model | MGI Sequence Detail 6064 C57BL/6J ±  kb
    transcript NM_178020 RefSeq | MGI Sequence Detail 1830 ZRU/MplStud  
    polypeptide Q8VEI3 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory