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Vps52 Gene Detail
Summary
  • Symbol
    Vps52
  • Name
    VPS52 GARP complex subunit
  • Synonyms
    ARE1, D430041K17Rik, Sacm2l, tcl-w5, tclw5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330304
    NCBI Gene: 224705
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34174786-34186009 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330304
 protein coding gene Chr17:34174753-34186012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023549
 protein coding gene Chr17:33905772-33918428 (+)
A/J MGP_AJ_G0023510
 protein coding gene Chr17:32738911-32749506 (+)
AKR/J MGP_AKRJ_G0023476
 protein coding gene Chr17:33133893-33144758 (+)
BALB/cJ MGP_BALBcJ_G0023513
 protein coding gene Chr17:32911128-32922266 (+)
C3H/HeJ MGP_C3HHeJ_G0023275
 protein coding gene Chr17:33494448-33505043 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023955
 protein coding gene Chr17:35188777-35201986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021433
 protein coding gene Chr17:30289074-30290541 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0023380
 protein coding gene Chr17:32116372-32126826 (+)
FVB/NJ MGP_FVBNJ_G0023349
 protein coding gene Chr17:31983148-31992277 (+)
LP/J MGP_LPJ_G0023458
 protein coding gene Chr17:34180426-34190685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023371
 protein coding gene Chr17:35639614-35651012 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023996
 protein coding gene Chr17:33462049-33492207 (+)
PWK/PhJ MGP_PWKPhJ_G0022525
 protein coding gene Chr17:31031015-31049534 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VPS52, VPS52 subunit of GARP complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS52, VPS52 subunit of GARP complex
  • Synonyms
    ARE1, dJ1033B10.5, SAC2, SACM2L
  • Links
    NCBI Gene ID: 6293
    neXtProt AC: NX_Q8N1B4
    UniProt: Q8N1B4

  • Chr Location
    6p21.32; chr6:33250272-33272047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024319 Ensembl Gene Model | MGI Sequence Detail 11224 C57BL/6J ±  kb
    transcript ENSMUST00000025178 Ensembl | MGI Sequence Detail 3383 Not Applicable  
    polypeptide ENSMUSP00000025178 Ensembl | MGI Sequence Detail 723 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14784, MGD-MRK-14804, MGI:2443974, MGI:98531
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:23652 Dunn LC, et al., Studies of the Genetic Variability in Wild Populations of House Mice. I. Analysis of Seven Alleles at Locus T. Genetics. 1956 May;41(3):344-52
    • Latest
      J:346420 Ibuchi K, et al., The Vps52 subunit of the GARP and EARP complexes is a novel Arf6-interacting protein that negatively regulates neurite outgrowth of hippocampal neurons. Brain Res. 2020 Oct 15;1745:146905
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory