Dmrt2 MGI Mouse Gene Detail - MGI:1330307 - doublesex and mab-3 related transcription factor 2

Symbol

Dmrt2
Name

doublesex and mab-3 related transcription factor 2
Synonyms

Terra

Feature Type

protein coding gene
IDs

MGI:1330307
NCBI Gene: 226049
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:25649775-25656355 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 20.53 cM
Mapping Data

1 experiment

SNPs within 2kb

283 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330307	protein coding gene	Chr19:25649758-25656355 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025004	protein coding gene	Chr19:23985881-23992400 (+)
A/J	MGP_AJ_G0024981	protein coding gene	Chr19:22681937-22688525 (+)
AKR/J	MGP_AKRJ_G0024949	protein coding gene	Chr19:23547950-23554866 (+)
BALB/cJ	MGP_BALBcJ_G0024980	protein coding gene	Chr19:22728733-22735296 (+)
C3H/HeJ	MGP_C3HHeJ_G0024736	protein coding gene	Chr19:23539678-23547618 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025421	protein coding gene	Chr19:24721494-24728092 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022840	protein coding gene	Chr19:22807209-22813700 (+)
CAST/EiJ	MGP_CASTEiJ_G0024206	protein coding gene	Chr19:23280300-23286807 (+)
CBA/J	MGP_CBAJ_G0024714	protein coding gene	Chr19:25788472-25794992 (+)
DBA/2J	MGP_DBA2J_G0024846	protein coding gene	Chr19:22675331-22681847 (+)
FVB/NJ	MGP_FVBNJ_G0024808	protein coding gene	Chr19:22577777-22584348 (+)
LP/J	MGP_LPJ_G0024931	protein coding gene	Chr19:23941340-23947608 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024835	protein coding gene	Chr19:25767813-25775665 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025476	protein coding gene	Chr19:23564599-23571108 (+)
PWK/PhJ	MGP_PWKPhJ_G0023954	protein coding gene	Chr19:22320338-22326208 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023758	protein coding gene	Chr19:22838922-22845398 (+)
WSB/EiJ	MGP_WSBEiJ_G0024273	protein coding gene	Chr19:23591605-23598143 (+)

Human Ortholog

DMRT2, doublesex and mab-3 related transcription factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMRT2, doublesex and mab-3 related transcription factor 2
Synonyms

DSXL-2
Links

HGNC:2935

NCBI Gene ID: 10655

neXtProt AC: NX_Q9Y5R5

UniProt: Q9Y5R5
Chr Location

9p24.3; chr9:1049858-1057552 (+) GRCh38

MGI Vertebrate Homology

Dmrt2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DMRT2
Gene Tree

Dmrt2

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Phenotype Summary

26 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

912
Tissues

102
cDNA Data

21
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dmrt2

ZFIN dmrt2a, dmrt2b

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS29719.1

Ensembl

ENSMUSG00000048138 (Evidence)
NCBI Gene

226049

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048138	Ensembl Gene Model \| MGI Sequence Detail	6581	C57BL/6J	± kb
transcript	ENSMUST00000053068	Ensembl \| MGI Sequence Detail	2337	Not Applicable
polypeptide	ENSMUSP00000059654	Ensembl \| MGI Sequence Detail	561	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006543 doublesex- and mab-3-related transcription factor 2

(term hierarchy)
InterPro Domains

IPR001275 DM DNA-binding domain

IPR036407 DM DNA-binding domain superfamily

IPR026607 DMRT family

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All nucleic 31

cDNA 22

Primer pair 7

Other 2

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 8
Earliest

J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
Latest

J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539

TSS for Dmrt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155703	Chr19:25649772-25649784 (+)	3 bp
Tssr155704	Chr19:25652581-25652584 (+)	2,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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