About   Help   FAQ
Sprr2b Gene Detail
Summary
  • Symbol
    Sprr2b
  • Name
    small proline-rich protein 2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330352
    NCBI Gene: 20756
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:92224012-92225448 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330352
 protein coding gene Chr3:92223927-92225448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027488
 protein coding gene Chr3:92747930-92749395 (+)
A/J MGP_AJ_G0027455
 protein coding gene Chr3:89839411-89841501 (+)
AKR/J MGP_AKRJ_G0027417
 protein coding gene Chr3:91943242-91944707 (+)
BALB/cJ MGP_BALBcJ_G0027464
 protein coding gene Chr3:89648970-89650435 (+)
C3H/HeJ MGP_C3HHeJ_G0027203
 protein coding gene Chr3:92164435-92165900 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027907
 protein coding gene Chr3:96180817-96182285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025258
 protein coding gene Chr3:86477107-86478576 (+)
CAST/EiJ MGP_CASTEiJ_G0026651
 protein coding gene Chr3:91563412-91566282 (+)
CBA/J MGP_CBAJ_G0027178
 protein coding gene Chr3:99585900-99587365 (+)
DBA/2J MGP_DBA2J_G0027315
 protein coding gene Chr3:89150636-89152101 (+)
FVB/NJ MGP_FVBNJ_G0027283
 protein coding gene Chr3:87325590-87327055 (+)
LP/J MGP_LPJ_G0027424
 protein coding gene Chr3:93978471-93979936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027307
 protein coding gene Chr3:105827789-105829227 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027966
 protein coding gene Chr3:91655718-91657183 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026202
 protein coding gene Chr3:89958164-89996637 (+)
WSB/EiJ MGP_WSBEiJ_G0026733
 protein coding gene Chr3:92062531-92063969 (+)



Homology
less
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    6
  • cDNA Data
    3
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20756 NCBI Gene Model | MGI Sequence Detail 1437 C57BL/6J ±  kb
transcript NM_011469 RefSeq | MGI Sequence Detail 755 ZRU/MplStud  
polypeptide O70554 UniProt | EBI | MGI Sequence Detail 98 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 4
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:113697 Gibbs S, et al., Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics. 1993 Jun;16(3):630-7
  • Latest
    J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory