Atp10a MGI Mouse Gene Detail - MGI:1330809

Symbol

Atp10a
Name

ATPase, class V, type 10A
Synonyms

Atp10c, pfatp

Feature Type

protein coding gene
IDs

MGI:1330809
NCBI Gene: 11982
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:58305914-58479168 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 33.88 cM
Mapping Data

3 experiments

SNPs within 2kb

5421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330809	protein coding gene	Chr7:58305896-58479783 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032321	protein coding gene	Chr7:59485674-59664160 (+)
A/J	MGP_AJ_G0032300	protein coding gene	Chr7:58604854-58777972 (+)
AKR/J	MGP_AKRJ_G0032236	protein coding gene	Chr7:59897410-60079035 (+)
BALB/cJ	MGP_BALBcJ_G0032312	protein coding gene	Chr7:58155771-58330971 (+)
C3H/HeJ	MGP_C3HHeJ_G0032025	protein coding gene	Chr7:60287306-60465655 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032805	protein coding gene	Chr7:62187444-62370624 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029812	protein coding gene	Chr7:61076082-61251055 (+)
CAST/EiJ	MGP_CASTEiJ_G0031354	protein coding gene	Chr7:51459249-51641749 (+)
CBA/J	MGP_CBAJ_G0031990	protein coding gene	Chr7:64341126-64536198 (+)
DBA/2J	MGP_DBA2J_G0032147	protein coding gene	Chr7:57544489-57719554 (+)
FVB/NJ	MGP_FVBNJ_G0032101	protein coding gene	Chr7:57514296-57693862 (+)
LP/J	MGP_LPJ_G0032228	protein coding gene	Chr7:60613940-60794489 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032138	protein coding gene	Chr7:63933443-64119567 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032822	protein coding gene	Chr7:58960668-59137884 (+)
PWK/PhJ	MGP_PWKPhJ_G0031074	protein coding gene	Chr7:50763212-50940693 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030915	protein coding gene	Chr7:46929933-47104741 (+)
WSB/EiJ	MGP_WSBEiJ_G0031472	protein coding gene	Chr7:59537984-59717536 (+)

Human Ortholog

ATP10A, ATPase phospholipid transporting 10A (putative)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP10A, ATPase phospholipid transporting 10A (putative)
Synonyms

ATP10C, ATPVA, ATPVC
Links

HGNC:13542

NCBI Gene ID: 57194

neXtProt AC: NX_O60312

UniProt: O60312
Chr Location

15q12; chr15:25672237-25865184 (-) GRCh38

MGI Vertebrate Homology

Atp10a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP10A
Gene Tree

Atp10a

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References

5 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Endonuclease-mediated

5
Radiation induced

2
Targeted

3
Transgenic

1
Genomic Mutations

5 involving Atp10a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Disruption of this gene at the distal end of the p^23DFiOD deletion may be responsible for the obesity phenotypes associated with that deletion.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

123
cDNA Data

47
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp10a

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All Sequences

58
RefSeq

13
UniProt

5
CCDS

CCDS39972.1

Ensembl

ENSMUSG00000025324 (Evidence)
NCBI Gene

11982

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025324	Ensembl Gene Model \| MGI Sequence Detail	173255	C57BL/6J	± kb
transcript	ENSMUST00000168747	Ensembl \| MGI Sequence Detail	5419	Not Applicable
polypeptide	ENSMUSP00000129811	Ensembl \| MGI Sequence Detail	1508	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032700 phospholipid-transporting ATPase VA

(term hierarchy)
EC

7.6.2.1
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR032630 P-type ATPase, C-terminal

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR032631 P-type ATPase, N-terminal

IPR018303 P-type ATPase, phosphorylation site

IPR006539 P-type ATPase, subfamily IV

IPR023298 P-type ATPase, transmembrane domain superfamily
GlyGen

O54827 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

cDNA 47

Primer pair 3

Microarray probesets 3

Summaries

All 88

Developmental Gene Expression 8

Diseases 5

Gene Ontology 9

Phenotypes 48
Earliest

J:29903 Russell LB, et al., Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics. 1995 Dec;141(4):1547-62
Latest

J:345883 Norris AC, et al., ATP10A deficiency results in male-specific infertility in mice. Front Cell Dev Biol. 2024;12:1310593

TSS for Atp10a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66946	Chr7:58307929-58308042 (+)	2,072 bp
Tssr66947	Chr7:58308103-58308124 (+)	2,200 bp
Tssr66948	Chr7:58308129-58308159 (+)	2,230 bp
Tssr66949	Chr7:58308168-58308179 (+)	2,260 bp
Tssr66950	Chr7:58347069-58347080 (+)	41,161 bp
Tssr66951	Chr7:58359609-58359611 (+)	53,696 bp
Tssr66952	Chr7:58360264-58360265 (+)	54,351 bp
Tssr66953	Chr7:58400773-58400778 (+)	94,862 bp
Tssr66954	Chr7:58405127-58405139 (+)	99,219 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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