About   Help   FAQ
Trp63 Gene Detail
Summary
  • Symbol
    Trp63
  • Name
    transformation related protein 63
  • Synonyms
    deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330810
    NCBI Gene: 22061
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:25502513-25710842 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 17.37 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5588 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330810
 protein coding gene Chr16:25502513-25710852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022691
 protein coding gene Chr16:23386506-23605173 (+)
A/J MGP_AJ_G0022653
 protein coding gene Chr16:22282048-22493281 (+)
AKR/J MGP_AKRJ_G0022627
 protein coding gene Chr16:23199244-23414253 (+)
BALB/cJ MGP_BALBcJ_G0022658
 protein coding gene Chr16:22481885-22696167 (+)
C3H/HeJ MGP_C3HHeJ_G0022422
 protein coding gene Chr16:23290938-23512358 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023107
 protein coding gene Chr16:23925339-24145905 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020625
 protein coding gene Chr16:22879658-23085208 (+)
CAST/EiJ MGP_CASTEiJ_G0021951
 protein coding gene Chr16:23351411-23567152 (+)
CBA/J MGP_CBAJ_G0022393
 protein coding gene Chr16:24913638-25136897 (+)
DBA/2J MGP_DBA2J_G0022525
 protein coding gene Chr16:22225192-22436453 (+)
FVB/NJ MGP_FVBNJ_G0022501
 protein coding gene Chr16:22218875-22427341 (+)
LP/J MGP_LPJ_G0022593
 protein coding gene Chr16:23167699-23387661 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022520
 protein coding gene Chr16:24349086-24574095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023119
 protein coding gene Chr16:23148550-23367410 (+)
PWK/PhJ MGP_PWKPhJ_G0021690
 protein coding gene Chr16:22515268-22729775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021521
 protein coding gene Chr16:22930307-23140012 (+)
WSB/EiJ MGP_WSBEiJ_G0021995
 protein coding gene Chr16:23105126-23321144 (+)



Homology
more
  • Human Ortholog
    TP63, tumor protein p63
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP63, tumor protein p63
  • Synonyms
    AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
  • Links
    NCBI Gene ID: 8626
    neXtProt AC: NX_Q9H3D4
    UniProt: Q9H3D4

  • Chr Location
    3q28; chr3:189596746-189897276 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Trp63 mouse models; 12 with human TP63 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 4 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    170 phenotypes from 20 alleles in 17 genetic backgrounds
    26 phenotypes from multigenic genotypes
    164 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamous epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have craniofacial anomalies, missing or truncated limbs, and small genitalia, and they die perinatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    151
  • GO References
    56
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1929
  • Tissues
    375
  • cDNA Data
    41
  • Literature Summary
    373
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22061 NCBI Gene Model | MGI Sequence Detail 208330 C57BL/6J ±  kb
    transcript NM_001127259 RefSeq | MGI Sequence Detail 5382 ZRU/MplStud  
    polypeptide O88898 UniProt | EBI | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 3
      cDNA 41
      Primer pair 34
      Other 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1196329, MGI:1332227, MGI:2146440
    References
    more
    • Summaries
      All 591
      Developmental Gene Expression 373
      Diseases 6
      Gene Ontology 56
      Phenotypes 164
    • Earliest
      J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
    • Latest
      J:355654 Cai S, et al., Single-cell transcriptome and chromatin accessibility mapping of upper lip and primary palate fusion. J Cell Mol Med. 2024 Oct;28(19):e70128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory