About   Help   FAQ
Csrp3 Gene Detail
Summary
  • Symbol
    Csrp3
  • Name
    cysteine and glycine-rich protein 3
  • Synonyms
    CRP3, MLP, muscle LIM protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330824
    NCBI Gene: 13009
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48480146-48497781 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    690 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330824
 protein coding gene Chr7:48480146-48497799 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032295
 protein coding gene Chr7:49435526-49453167 (-)
A/J MGP_AJ_G0032274
 protein coding gene Chr7:48741654-48759269 (-)
AKR/J MGP_AKRJ_G0032210
 protein coding gene Chr7:49885508-49903141 (-)
BALB/cJ MGP_BALBcJ_G0032286
 protein coding gene Chr7:48389748-48407391 (-)
C3H/HeJ MGP_C3HHeJ_G0031999
 protein coding gene Chr7:50259648-50277269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032779
 protein coding gene Chr7:51742048-51759715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029785
 protein coding gene Chr7:51917241-51935243 (-)
CAST/EiJ MGP_CASTEiJ_G0031327
 protein coding gene Chr7:41640900-41658652 (-)
CBA/J MGP_CBAJ_G0031964
 protein coding gene Chr7:53478432-53496059 (-)
DBA/2J MGP_DBA2J_G0032121
 protein coding gene Chr7:47951828-47969491 (-)
FVB/NJ MGP_FVBNJ_G0032075
 protein coding gene Chr7:47878695-47896322 (-)
LP/J MGP_LPJ_G0032202
 protein coding gene Chr7:50398382-50417438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032112
 protein coding gene Chr7:52601839-52619464 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032796
 protein coding gene Chr7:48865204-48882859 (-)
PWK/PhJ MGP_PWKPhJ_G0031047
 protein coding gene Chr7:41287320-41305315 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030888
 protein coding gene Chr7:37035930-37054942 (-)
WSB/EiJ MGP_WSBEiJ_G0031445
 protein coding gene Chr7:49521172-49538818 (-)



Homology
more
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Synonyms
    CLP, CMD1M, CMH12, CRP3, LMO4, MLP
  • Links
    NCBI Gene ID: 8048
    neXtProt AC: NX_P50461
    UniProt: P50461

  • Chr Location
    11p15.1; chr11:19182030-19210571 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Csrp3 mouse models; 4 with human CSRP3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    85
  • cDNA Data
    11
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030470 Ensembl Gene Model | MGI Sequence Detail 17636 C57BL/6J ±  kb
    transcript ENSMUST00000032658 Ensembl | MGI Sequence Detail 877 Not Applicable  
    polypeptide ENSMUSP00000032658 Ensembl | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 13
      Primer pair 4
      Other 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 19
      Diseases 4
      Gene Ontology 15
      Phenotypes 51
    • Earliest
      J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
    • Latest
      J:348385 Eden M, et al., Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy. J Biol Chem. 2024 Apr 3;300(5):107255
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory