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Lgmn Gene Detail
Summary
  • Symbol
    Lgmn
  • Name
    legumain
  • Synonyms
    AEP, preprolegumain, Prsc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330838
    NCBI Gene: 19141
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102360341-102405987 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330838
 protein coding gene Chr12:102360341-102406072 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020031
 protein coding gene Chr12:104028813-104067249 (-)
A/J MGP_AJ_G0019987
 protein coding gene Chr12:100037829-100073549 (-)
AKR/J MGP_AKRJ_G0019963
 protein coding gene Chr12:102877347-102912930 (-)
BALB/cJ MGP_BALBcJ_G0019973
 protein coding gene Chr12:100367614-100403499 (-)
C3H/HeJ MGP_C3HHeJ_G0019775
 protein coding gene Chr12:103337777-103375750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020422
 protein coding gene Chr12:107275506-107321965 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018035
 protein coding gene Chr12:97059792-97095661 (-)
CAST/EiJ MGP_CASTEiJ_G0019321
 protein coding gene Chr12:98165402-98204190 (-)
CBA/J MGP_CBAJ_G0019747
 protein coding gene Chr12:111245961-111292341 (-)
DBA/2J MGP_DBA2J_G0019858
 protein coding gene Chr12:99555113-99593446 (-)
FVB/NJ MGP_FVBNJ_G0019847
 protein coding gene Chr12:98283898-98321663 (-)
LP/J MGP_LPJ_G0019934
 protein coding gene Chr12:103882459-103923124 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019887
 protein coding gene Chr12:114719975-114757128 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020451
 protein coding gene Chr12:102378887-102416248 (-)
PWK/PhJ MGP_PWKPhJ_G0019084
 protein coding gene Chr12:94108055-94146689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018880
 protein coding gene Chr12:96552261-96594963 (-)
WSB/EiJ MGP_WSBEiJ_G0019375
 protein coding gene Chr12:103270066-103309475 (-)



Homology
more
  • Human Ortholog
    LGMN, legumain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGMN, legumain
  • Synonyms
    AEP, LGMN1, PRSC1
  • Links
    NCBI Gene ID: 5641
    neXtProt AC: NX_Q99538
    UniProt: Q99538

  • Chr Location
    14q32.12; chr14:92703807-92748679 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lgmn mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 3 alleles in 4 genetic backgrounds
    5 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele exhibit slow postnatal weight gain, develop features of hemophagocytic syndrome, and accumulate giant lysosomes in renal tubule cells. Homozygotes for another null allele display impaired TLR9 signaling in dendritic cells, progressive kidney pathology, and proteinuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    22
  • cDNA Data
    166
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19141 NCBI Gene Model | MGI Sequence Detail 45647 C57BL/6J ±  kb
    transcript NM_011175 RefSeq | MGI Sequence Detail 1921 C57BL/6  
    polypeptide O89017 UniProt | EBI | MGI Sequence Detail 435 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 167
      cDNA 166
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144882, MGI:2144957
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 14
      Phenotypes 44
    • Earliest
      J:50324 Chen JM, et al., Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J. 1998 Oct 1;335(Pt 1):111-7
    • Latest
      J:351247 Wang J, et al., A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice. Brain Behav Immun. 2024 Mar 29;119:56-83
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory