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Ugcg Gene Detail
Summary
  • Symbol
    Ugcg
  • Name
    UDP-glucose ceramide glucosyltransferase
  • Synonyms
    Epcs21, GlcT-1, Ugcgl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332243
    NCBI Gene: 22234
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:59189452-59222833 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 32.44 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332243
 protein coding gene Chr4:59189257-59222833 (+)
129S1/SvImJ ENSMUSG00200004021
 protein coding gene Chr4:55248172-55281543 (+)
A/J ENSMUSG00195008042
 protein coding gene Chr4:55641465-55674834 (+)
AKR/J ENSMUSG00220005866
 protein coding gene Chr4:55425004-55458374 (+)
BALB/cJ ENSMUSG00180026826
 protein coding gene Chr4:55236356-55269735 (+)
C3H/HeJ ENSMUSG00175021340
 protein coding gene Chr4:55392568-55425938 (+)
C57BL/6NJ ENSMUSG00215018859
 protein coding gene Chr4:55246660-55280241 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026061
 protein coding gene Chr4:52583113-52616936 (+)
CAST/EiJ ENSTCUG00005008065
 protein coding gene Chr4:55478419-55511993 (+)
CBA/J ENSMUSG00210004746
 protein coding gene Chr4:55135600-55168965 (+)
DBA/2J ENSMUSG00185017552
 protein coding gene Chr4:55477186-55510556 (+)
FVB/NJ ENSMUSG00205012698
 protein coding gene Chr4:54702848-54736215 (+)
JF1/MsJ ENSUMUG00000014510
 protein coding gene Chr4:55707356-55741111 (+)
LP/J ENSMUSG00230003051
 protein coding gene Chr4:59030682-59064040 (+)
NOD/ShiLtJ ENSMUSG00190037750
 protein coding gene Chr4:55315629-55348998 (+)
NZO/HlLtJ ENSMUSG00225012786
 protein coding gene Chr4:63627176-63660541 (+)
PWK/PhJ ENSLUMG00010007100
 protein coding gene Chr4:54577996-54611766 (+)
SPRET/EiJ ENSMSPG00010027746
 protein coding gene Chr4:55746468-55780153 (+)
WSB/EiJ ENSIUOG00005020272
 protein coding gene Chr4:55132599-55165951 (+)



Homology
more
  • Human Ortholog
    UGCG, UDP-glucose ceramide glucosyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGCG, UDP-glucose ceramide glucosyltransferase
  • Synonyms
    GCS, GLCT1
  • Links
    NCBI Gene ID: 7357
    UniProt: Q16739

  • Chr Location
    9q31.3; chr9:111896814-111935374 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 6 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
At embryonic day 7.5, embryos homozygous for a null mutation exhibit decreased size, markedly reduced extraembryonic tissues and a large increase in cells undergoing apoptosis. Mutants die by embryonic day 8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    113
  • cDNA Data
    108
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22234 NCBI Gene Model | MGI Sequence Detail 33382 C57BL/6J ±  kb
    transcript NM_011673 RefSeq | MGI Sequence Detail 3719 ZRU/MplStud  
    polypeptide O88693 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 2
      cDNA 108
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1860296, MGI:2140489, MGI:2140685
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 32
    • Earliest
      J:48204 Ichikawa S, et al., Molecular cloning and expression of mouse ceramide glucosyltransferase. Biochem Mol Biol Int. 1998 May;44(6):1193-202
    • Latest
      J:379106 Jiang L, et al., Glucosylceramide regulates depression through activating peroxisome proliferator-activated receptor gamma in dorsal striatum. Theranostics. 2026;16(6):2845-2865
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory