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Slc33a1 Gene Detail
Summary
  • Symbol
    Slc33a1
  • Name
    solute carrier family 33 (acetyl-CoA transporter), member 1
  • Synonyms
    Acatn, D630022N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332247
    NCBI Gene: 11416
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:63849744-63872154 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.08 cM, cytoband E1-E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332247
 protein coding gene Chr3:63840928-63872189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027264
 protein coding gene Chr3:62982964-63011354 (-)
A/J MGP_AJ_G0027224
 protein coding gene Chr3:61097552-61127894 (-)
AKR/J MGP_AKRJ_G0027194
 protein coding gene Chr3:62312728-62345314 (-)
BALB/cJ MGP_BALBcJ_G0027237
 protein coding gene Chr3:60873428-60902047 (-)
C3H/HeJ MGP_C3HHeJ_G0026980
 protein coding gene Chr3:62553579-62582906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027683
 protein coding gene Chr3:65282409-65315152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025037
 protein coding gene Chr3:57598956-57629608 (-)
CAST/EiJ MGP_CASTEiJ_G0026432
 protein coding gene Chr3:62686008-62719039 (-)
CBA/J MGP_CBAJ_G0026956
 protein coding gene Chr3:67387446-67422860 (-)
DBA/2J MGP_DBA2J_G0027090
 protein coding gene Chr3:60514560-60542918 (-)
FVB/NJ MGP_FVBNJ_G0027058
 protein coding gene Chr3:59319677-59348917 (-)
LP/J MGP_LPJ_G0027201
 protein coding gene Chr3:63830072-63859518 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027075
 protein coding gene Chr3:71863774-71896316 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027741
 protein coding gene Chr3:62249184-62278290 (-)
PWK/PhJ MGP_PWKPhJ_G0026164
 protein coding gene Chr3:60095900-60126727 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025977
 protein coding gene Chr3:61778759-61810185 (-)
WSB/EiJ MGP_WSBEiJ_G0026506
 protein coding gene Chr3:62383594-62414855 (-)



Homology
more
  • Human Ortholog
    SLC33A1, solute carrier family 33 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC33A1, solute carrier family 33 member 1
  • Synonyms
    ACATN, AT-1, AT1, CCHLND, HPBDS, SPG42
  • Links
    NCBI Gene ID: 9197
    neXtProt AC: NX_O00400
    UniProt: O00400

  • Chr Location
    3q25.31; chr3:155821024-155854456 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC33A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a serine to arginine substitution at amino acid 113 show early embryonic growth arrest. Adult heterozygotes display aberrant inflammatory response, increased propensity to infections and malignancies, degenerative features of the PNS and CNS, and abnormal induction of autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    29
  • cDNA Data
    85
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11416 NCBI Gene Model | MGI Sequence Detail 22411 C57BL/6J ±  kb
    transcript NM_015728 RefSeq | MGI Sequence Detail 3122 C57BL/6  
    polypeptide Q99J27 UniProt | EBI | MGI Sequence Detail 550 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015085 acetyl-coenzyme A transporter 1
      (term hierarchy)
    • InterPro Domains
      IPR024371 Acetyl-coenzyme A transporter 1-like
      IPR004752 AmpG-like permease/Acetyl-coenzyme A transporter 1
      IPR036259 MFS transporter superfamily
    • GlyGen
      Q99J27 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 85
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139668, MGI:2139794, MGI:2442761
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:53140 Bora RS, et al., Assignment1 of a putative acetyl-CoA transporter gene (Acatn) to mouse chromosome band 3E1-E3 by in situ hybridization. Cytogenet Cell Genet. 1998;83(1-2):78-9
    • Latest
      J:317315 Dieterich IA, et al., Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Sci Rep. 2021 Jan 21;11(1):2013
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory