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Mrpl40 Gene Detail
Summary
  • Symbol
    Mrpl40
  • Name
    mitochondrial ribosomal protein L40
  • Synonyms
    Nlvcf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332635
    NCBI Gene: 18100
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18690768-18695612 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332635
 protein coding gene Chr16:18690767-18695875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022622
 protein coding gene Chr16:16138435-16143184 (-)
A/J MGP_AJ_G0022583
 protein coding gene Chr16:15327323-15332072 (-)
AKR/J MGP_AKRJ_G0022560
 protein coding gene Chr16:15951966-15956721 (-)
BALB/cJ MGP_BALBcJ_G0022588
 protein coding gene Chr16:15486052-15490882 (-)
C3H/HeJ MGP_C3HHeJ_G0022355
 protein coding gene Chr16:16104073-16109588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023037
 protein coding gene Chr16:16455740-16460195 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020557
 protein coding gene Chr16:15355423-15360193 (-)
CAST/EiJ MGP_CASTEiJ_G0021882
 protein coding gene Chr16:15988535-15994127 (-)
CBA/J MGP_CBAJ_G0022324
 protein coding gene Chr16:17132308-17137056 (-)
DBA/2J MGP_DBA2J_G0022456
 protein coding gene Chr16:15238630-15243719 (-)
FVB/NJ MGP_FVBNJ_G0022431
 protein coding gene Chr16:15302705-15307377 (-)
LP/J MGP_LPJ_G0022523
 protein coding gene Chr16:15890507-15895312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022453
 protein coding gene Chr16:16773626-16778406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023048
 protein coding gene Chr16:15867412-15873188 (-)
PWK/PhJ MGP_PWKPhJ_G0021624
 protein coding gene Chr16:15525516-15530334 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021452
 protein coding gene Chr16:15813987-15818716 (-)
WSB/EiJ MGP_WSBEiJ_G0021928
 protein coding gene Chr16:15891642-15895932 (-)



Homology
more
  • Human Ortholog
    MRPL40, mitochondrial ribosomal protein L40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL40, mitochondrial ribosomal protein L40
  • Synonyms
    L40mt, mL40, MRP-L22, MRPL22, MRP-L40, NLVCF, URIM
  • Links
    NCBI Gene ID: 64976
    neXtProt AC: NX_Q9NQ50
    UniProt: Q9NQ50

  • Chr Location
    22q11.21; chr22:19432545-19436075 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    60
  • cDNA Data
    48
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022706 Ensembl Gene Model | MGI Sequence Detail 4845 C57BL/6J ±  kb
transcript ENSMUST00000023391 Ensembl | MGI Sequence Detail 1280 Not Applicable  
polypeptide ENSMUSP00000023391 Ensembl | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010601 large ribosomal subunit protein mL40
    (term hierarchy)
  • InterPro Domains
    IPR019192 Large ribosomal subunit protein mL40
    IPR039145 Large ribosomal subunit protein mL40, metazoa/plants
  • GlyGen
    Q9Z2Q5 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 61
    Genomic 10
    cDNA 48
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 95
    Developmental Gene Expression 8
    Diseases 4
    Gene Ontology 9
    Phenotypes 58
  • Earliest
    J:50534 Funke B, et al., Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11. Genomics. 1998 Oct 15;53(2):146-54
  • Latest
    J:342597 Rummell BP, et al., Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition. Nat Commun. 2023 Nov 15;14(1):7388
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory