Mpeg1 MGI Mouse Gene Detail - MGI:1333743 - macrophage expressed gene 1

Symbol

Mpeg1
Name

macrophage expressed gene 1
Synonyms

Mpg-1, MPS1, Perforin-2

Feature Type

protein coding gene
IDs

MGI:1333743
NCBI Gene: 17476
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:12438143-12442647 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.72 cM
Mapping Data

1 experiment

SNPs within 2kb

249 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333743	protein coding gene	Chr19:12438134-12442649 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024905	protein coding gene	Chr19:9920521-9925026 (+)
A/J	MGP_AJ_G0024881	protein coding gene	Chr19:9297469-9301896 (+)
AKR/J	MGP_AKRJ_G0024853	protein coding gene	Chr19:9757939-9762441 (+)
BALB/cJ	MGP_BALBcJ_G0024880	protein coding gene	Chr19:9297096-9301524 (+)
C3H/HeJ	MGP_C3HHeJ_G0024644	protein coding gene	Chr19:9646436-9650937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025329	protein coding gene	Chr19:10464110-10468615 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022755	protein coding gene	Chr19:9932922-9937350 (+)
CAST/EiJ	MGP_CASTEiJ_G0024113	protein coding gene	Chr19:9222066-9226494 (+)
CBA/J	MGP_CBAJ_G0024618	protein coding gene	Chr19:10546208-10550801 (+)
DBA/2J	MGP_DBA2J_G0024750	protein coding gene	Chr19:9334629-9339133 (+)
FVB/NJ	MGP_FVBNJ_G0024713	protein coding gene	Chr19:9359940-9364418 (+)
LP/J	MGP_LPJ_G0024833	protein coding gene	Chr19:9993105-9997607 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024740	protein coding gene	Chr19:10327908-10332335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025377	protein coding gene	Chr19:9737279-9742347 (+)
PWK/PhJ	MGP_PWKPhJ_G0023863	protein coding gene	Chr19:8801093-8805516 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023666	protein coding gene	Chr19:8873918-8878346 (+)
WSB/EiJ	MGP_WSBEiJ_G0024181	protein coding gene	Chr19:9598363-9602867 (+)

Human Ortholog

MPEG1, macrophage expressed 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPEG1, macrophage expressed 1
Synonyms

IMD77, Mpg-1, MPG1, MPS1, P-2
Links

HGNC:29619

NCBI Gene ID: 219972

neXtProt AC: NX_Q2M385

UniProt: Q2M385
Chr Location

11q12.1; chr11:59208510-59212927 (-) GRCh38

MGI Vertebrate Homology

Mpeg1 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: MPEG1
Gene Tree

Mpeg1

Diseases

1 with human MPEG1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

6
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

Mice homozygous for a knock-out allele exhibit increased in susceptibility to infection induced morbidity/mortality induced by an isogenic cif::aadA or wild-type version of Y. pseudotuberculosis.

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All GO Annotations

25
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

16
cDNA Data

78
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN mpeg1.1, mpeg1.2

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All Sequences

39
RefSeq

4
UniProt

5
CCDS

CCDS37926.1

Ensembl

ENSMUSG00000046805 (Evidence)
NCBI Gene

17476

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046805	Ensembl Gene Model \| MGI Sequence Detail	4505	C57BL/6J	± kb
transcript	ENSMUST00000081035	Ensembl \| MGI Sequence Detail	4334	Not Applicable
polypeptide	ENSMUSP00000108573	Ensembl \| MGI Sequence Detail	720	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010533 macrophage-expressed gene 1 protein

(term hierarchy)
PDB

6SB1, 6SB3, 6SB4, 6SB5, 8A1D, 8A1S
InterPro Domains

IPR039707 Macrophage-expressed gene 1 protein

IPR020864 Membrane attack complex component/perforin (MACPF) domain
GlyGen

A1L314 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 81

Genomic 1

cDNA 79

Primer pair 1

Microarray probesets 4

Summaries

All 52

Developmental Gene Expression 11

Gene Ontology 12

Phenotypes 11
Earliest

J:51737 Spilsbury K, et al., Isolation of a novel macrophage-specific gene by differential cDNA analysis. Blood. 1995 Mar 15;85(6):1620-9
Latest

J:337206 Rodriguez-Silvestre P, et al., Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science. 2023 Jun 23;380(6651):1258-1265

TSS for Mpeg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155319	Chr19:12438113-12438147 (+)	-13 bp
Tssr155320	Chr19:12438149-12438160 (+)	12 bp
Tssr155321	Chr19:12438173-12438189 (+)	38 bp
Tssr155322	Chr19:12438396-12438407 (+)	259 bp
Tssr155323	Chr19:12438453-12438465 (+)	316 bp
Tssr155324	Chr19:12438474-12438524 (+)	356 bp
Tssr155325	Chr19:12438536-12438547 (+)	399 bp
Tssr155326	Chr19:12442171-12442182 (+)	4,034 bp
Tssr155327	Chr19:12442266-12442270 (+)	4,125 bp
Tssr155328	Chr19:12442301-12442314 (+)	4,165 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24