Agfg1 MGI Mouse Gene Detail - MGI:1333754

Symbol

Agfg1
Name

ArfGAP with FG repeats 1
Synonyms

C130049H11Rik, D730048C23Rik, Hrb, Rip

Feature Type

protein coding gene
IDs

MGI:1333754
NCBI Gene: 15463
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:82817204-82878903 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 42.55 cM, cytoband C5
Mapping Data

3 experiments

SNPs within 2kb

1527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333754	protein coding gene	Chr1:82816738-82878903 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016220	protein coding gene	Chr1:83766338-83829944 (+)
A/J	MGP_AJ_G0016203	protein coding gene	Chr1:80795566-80857050 (+)
AKR/J	MGP_AKRJ_G0016160	protein coding gene	Chr1:82999117-83064596 (+)
BALB/cJ	MGP_BALBcJ_G0016158	protein coding gene	Chr1:80940485-81003627 (+)
C3H/HeJ	MGP_C3HHeJ_G0015988	protein coding gene	Chr1:83376367-83438727 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016611	protein coding gene	Chr1:86988270-87065584 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014331	protein coding gene	Chr1:76017848-76085199 (+)
CAST/EiJ	MGP_CASTEiJ_G0015574	protein coding gene	Chr1:82786848-82863839 (+)
CBA/J	MGP_CBAJ_G0015962	protein coding gene	Chr1:89784312-89853263 (+)
DBA/2J	MGP_DBA2J_G0016063	protein coding gene	Chr1:80082465-80144385 (+)
FVB/NJ	MGP_FVBNJ_G0016066	protein coding gene	Chr1:79179741-79243535 (+)
LP/J	MGP_LPJ_G0016136	protein coding gene	Chr1:84880297-84948025 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016086	protein coding gene	Chr1:93176588-93241795 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016658	protein coding gene	Chr1:83163472-83226948 (+)
PWK/PhJ	MGP_PWKPhJ_G0015359	protein coding gene	Chr1:79527037-79594380 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015137	protein coding gene	Chr1:82375094-82445020 (+)
WSB/EiJ	MGP_WSBEiJ_G0015634	protein coding gene	Chr1:82959395-83023983 (+)

Human Ortholog

AGFG1, ArfGAP with FG repeats 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGFG1, ArfGAP with FG repeats 1
Synonyms

HRB, RAB, RIP
Links

HGNC:5175

NCBI Gene ID: 3267

neXtProt AC: NX_P52594

UniProt: P52594
Chr Location

2q36.3; chr2:227472152-227561217 (+) GRCh38

MGI Vertebrate Homology

Agfg1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AGFG1
Gene Tree

Agfg1

Diseases

1 with Agfg1 mouse models

Human Disease

Mouse Models

oligoasthenoteratozoospermia

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

20
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Agfg1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis. Otherwise, males and females are normal and live a normal life span.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGFG1

Xenbase agfg1

ZFIN agfg1a

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All Sequences

112
RefSeq

50
UniProt

5
CCDS

CCDS15100.1, CCDS78634.1, CCDS83564.1, CCDS87854.1

Ensembl

ENSMUSG00000026159 (Evidence)
NCBI Gene

15463

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026159	Ensembl Gene Model \| MGI Sequence Detail	61700	C57BL/6J	± kb
transcript	ENSMUST00000190046	Ensembl \| MGI Sequence Detail	1805	Not Applicable
polypeptide	ENSMUSP00000140473	Ensembl \| MGI Sequence Detail	580	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003829 Arf-GAP domain and FG repeat-containing protein 1

(term hierarchy)
InterPro Domains

IPR052248 Arf-GAP domain and FG repeat-containing protein

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR001164 Arf GTPase activating protein
GlyGen

Q8K2K6 13 sites, 1 O-linked glycan (13 sites)

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All nucleic 14

cDNA 14

Microarray probesets 9

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MGI:1925111, MGI:2138506, MGI:2138706, MGI:2444445

Summaries

All 48

Developmental Gene Expression 1

Diseases 1

Gene Ontology 9

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:224421 Bryant JM, et al., Characterization of BRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015 Apr;35(8):1433-48

TSS for Agfg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7632	Chr1:82817170-82817239 (+)	1 bp
Tssr7633	Chr1:82817281-82817292 (+)	83 bp
Tssr7634	Chr1:82817372-82817405 (+)	185 bp
Tssr7635	Chr1:82817876-82817892 (+)	680 bp
Tssr7636	Chr1:82828922-82828930 (+)	11,722 bp
Tssr7637	Chr1:82836080-82836130 (+)	18,901 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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