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Krt6b Gene Detail
Summary
  • Symbol
    Krt6b
  • Name
    keratin 6B
  • Synonyms
    Krt2-6b, mK6[b]
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333768
    NCBI Gene: 16688
  • Member of
    Krt6 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101584458-101588722 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333768
 protein coding gene Chr15:101584458-101588728 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022344
 protein coding gene Chr15:99685477-99718521 (-)
AKR/J MGP_AKRJ_G0022319
 protein coding gene Chr15:102722748-102728256 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0020320
 protein coding gene Chr15:95514629-95518874 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0022214
 protein coding gene Chr15:99009084-99016451 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0022284
 protein coding gene Chr15:103947665-103957413 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021212
 protein coding gene Chr15:102585945-102597008 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KRT6A, keratin 6A
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT6A, keratin 6A
  • Synonyms
    CK6A, CK-6C, CK6C, CK6D, CK-6E, K6A, K6C, K6D, KRT6C, KRT6D, PC3
  • Links
    NCBI Gene ID: 3853
    neXtProt AC: NX_P02538
    UniProt: P02538

  • Chr Location
    12q13.13; chr12:52487176-52493257 (-)  GRCh38
  • Human Ortholog
    KRT6B, keratin 6B
  • Synonyms
    CK-6B, CK6B, K6B, KRTL1, PC2, PC4
  • Links
    NCBI Gene ID: 3854
    neXtProt AC: NX_P04259
    UniProt: P04259

  • Chr Location
    12q13.13; chr12:52446651-52452146 (-)  GRCh38
  • Human Ortholog
    KRT6C, keratin 6C
  • Synonyms
    K6E, KRT6E, PPKNEFD
  • Links
    NCBI Gene ID: 286887
    neXtProt AC: NX_P48668
    UniProt: P48668

  • Chr Location
    12q13.13; chr12:52468516-52473805 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KRT6A,KRT6B,KRT6C associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    3 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    8
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023041 Ensembl Gene Model | MGI Sequence Detail 4265 C57BL/6J ±  kb
    transcript ENSMUST00000023786 Ensembl | MGI Sequence Detail 2235 Not Applicable  
    polypeptide ENSMUSP00000023786 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR003054 Keratin, type II
      IPR032444 Keratin type II head
    • GlyGen
      Q9Z331 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146263
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 3
      Phenotypes 34
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory