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Klf12 Gene Detail
Summary
  • Symbol
    Klf12
  • Name
    Kruppel-like transcription factor 12
  • Synonyms
    2700063E05Rik, AP-2rep, B130052C06Rik, D530033K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333796
    NCBI Gene: 16597
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:100108068-100522115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 50.90 cM, cytoband E2.2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333796
 protein coding gene Chr14:100103617-100719681 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021619
 protein coding gene Chr14:96211601-96496081 (-)
A/J MGP_AJ_G0021577
 protein coding gene Chr14:93118133-93395273 (-)
AKR/J MGP_AKRJ_G0021553
 protein coding gene Chr14:95859884-96148141 (-)
BALB/cJ MGP_BALBcJ_G0021583
 protein coding gene Chr14:93454658-93732921 (-)
C3H/HeJ MGP_C3HHeJ_G0021361
 protein coding gene Chr14:95764753-96049124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022023
 protein coding gene Chr14:100129117-100426924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019563
 protein coding gene Chr14:90163162-90426037 (-)
CAST/EiJ MGP_CASTEiJ_G0020878
 protein coding gene Chr14:93066359-93346092 (-)
CBA/J MGP_CBAJ_G0021329
 protein coding gene Chr14:103835353-104155920 (-)
DBA/2J MGP_DBA2J_G0021453
 protein coding gene Chr14:92617554-92895265 (-)
FVB/NJ MGP_FVBNJ_G0021430
 protein coding gene Chr14:91650823-91919036 (-)
LP/J MGP_LPJ_G0021521
 protein coding gene Chr14:97010876-97305956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021457
 protein coding gene Chr14:106514862-106813948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022046
 protein coding gene Chr14:95391311-95674494 (-)
PWK/PhJ MGP_PWKPhJ_G0020621
 protein coding gene Chr14:89604730-89878906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020459
 protein coding gene Chr14:91368394-91655834 (-)
WSB/EiJ MGP_WSBEiJ_G0020931
 protein coding gene Chr14:95989344-96282171 (-)



Homology
more
  • Human Ortholog
    KLF12, KLF transcription factor 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF12, KLF transcription factor 12
  • Synonyms
    AP-2rep, AP2REP, HSPC122
  • Links
    NCBI Gene ID: 11278
    neXtProt AC: NX_Q9Y4X4
    UniProt: Q9Y4X4

  • Chr Location
    13q22.1; chr13:73686089-74306045 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    65
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000072294 Ensembl Gene Model | MGI Sequence Detail 414048 C57BL/6J ±  kb
    transcript ENSMUST00000228216 Ensembl | MGI Sequence Detail 5890 Not Applicable  
    polypeptide ENSMUSP00000153901 Ensembl | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1353650, MGI:1919848, MGI:1925972, MGI:2145611
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory