Rps7 MGI Mouse Gene Detail - MGI:1333818

Symbol

Rps7
Name

ribosomal protein S7
Synonyms

Mtu, S7

Feature Type

protein coding gene
IDs

MGI:1333818
NCBI Gene: 20115
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:28680853-28685952 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 10.99 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

317 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333818	protein coding gene	Chr12:28680846-28685952 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019643	protein coding gene	Chr12:26465732-26471184 (-)
A/J	MGP_AJ_G0019610	protein coding gene	Chr12:25754384-25759495 (-)
AKR/J	MGP_AKRJ_G0019581	protein coding gene	Chr12:26614310-26619422 (-)
BALB/cJ	MGP_BALBcJ_G0019587	protein coding gene	Chr12:26005425-26010531 (-)
C3H/HeJ	MGP_C3HHeJ_G0019391	protein coding gene	Chr12:26473956-26479067 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020034	protein coding gene	Chr12:27319497-27324595 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017659	protein coding gene	Chr12:25111069-25116523 (-)
CAST/EiJ	MGP_CASTEiJ_G0018946	protein coding gene	Chr12:21439031-21444375 (-)
CBA/J	MGP_CBAJ_G0019362	protein coding gene	Chr12:28281207-28286318 (-)
DBA/2J	MGP_DBA2J_G0019476	protein coding gene	Chr12:25606517-25611642 (-)
FVB/NJ	MGP_FVBNJ_G0019467	protein coding gene	Chr12:25407729-25412840 (-)
LP/J	MGP_LPJ_G0019546	protein coding gene	Chr12:26553684-26558797 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019502	protein coding gene	Chr12:27909343-27914907 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020074	protein coding gene	Chr12:26132413-26137538 (-)
PWK/PhJ	MGP_PWKPhJ_G0018713	protein coding gene	Chr12:20312550-20317699 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018501	protein coding gene	Chr12:20710963-20716064 (-)
WSB/EiJ	MGP_WSBEiJ_G0018997	protein coding gene	Chr12:26334596-26339732 (-)

Human Ortholog

RPS7, ribosomal protein S7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS7, ribosomal protein S7
Synonyms

DBA8, eS7, S7
Links

HGNC:10440

NCBI Gene ID: 6201

neXtProt AC: NX_P62081

UniProt: P62081
Chr Location

2p25.3; chr2:3575260-3580920 (+) GRCh38

MGI Vertebrate Homology

Rps7 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS7
Gene Tree

Rps7

Diseases

1 with human RPS7 associations

				Human Disease	Mouse Models
				Diamond-Blackfan anemia 8 IDs Diamond-Blackfan anemia 8 DOID:0111881 MESH:C567253 OMIM:612563

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 2 alleles in 5 genetic backgrounds
11 phenotypes from multigenic genotypes
10 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

2
Gene trapped

12
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for this ENU-induced mutation exhibit a white ventral patch and an extremely kinked or looped tail. Homozygotes exhibit an open hindbrain and defective neural crest production at E9.5.

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All GO Annotations

53
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

4
cDNA Data

13
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps7

ZFIN rps7

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All Sequences

47
RefSeq

2
UniProt

2
CCDS

CCDS25851.1

Ensembl

ENSMUSG00000061477 (Evidence)
NCBI Gene

20115

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061477	Ensembl Gene Model \| MGI Sequence Detail	5100	C57BL/6J	± kb
transcript	ENSMUST00000074267	Ensembl \| MGI Sequence Detail	954	Not Applicable
polypeptide	ENSMUSP00000073880	Ensembl \| MGI Sequence Detail	194	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014290 small ribosomal subunit protein eS7

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2, 7QVP
InterPro Domains

IPR000554 Small ribosomal subunit protein eS7

IPR047861 Small ribosomal subunit protein eS7, conserved site
GlyGen

P62082 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

Genomic 1

cDNA 13

Primer pair 1

Microarray probesets 5

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MGI:3043038

Summaries

All 38

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 6
Earliest

J:51004 Annilo T, et al., Isolation and characterization of the mouse ribosomal protein S7 gene. Biochem Mol Biol Int. 1998 Oct;46(2):287-95
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rps7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116019	Chr12:28685913-28685951 (-)	20 bp
Tssr116018	Chr12:28685890-28685904 (-)	55 bp
Tssr116017	Chr12:28685866-28685886 (-)	76 bp
Tssr116016	Chr12:28685842-28685864 (-)	99 bp
Tssr116015	Chr12:28685831-28685836 (-)	118 bp
Tssr116014	Chr12:28685232-28685239 (-)	716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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