Slc31a1 MGI Mouse Gene Detail - MGI:1333843 - solute carrier family 31, member 1

Symbol

Slc31a1
Name

solute carrier family 31, member 1
Synonyms

4930445G01Rik, Ctr1

Feature Type

protein coding gene
IDs

MGI:1333843
NCBI Gene: 20529
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:62278964-62310006 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 33.11 cM, cytoband C1-C2
Mapping Data

3 experiments

SNPs within 2kb

660 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333843	protein coding gene	Chr4:62278821-62310006 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028349	protein coding gene	Chr4:61340673-61374912 (+)
A/J	MGP_AJ_G0028310	protein coding gene	Chr4:59118969-59150207 (+)
AKR/J	MGP_AKRJ_G0028259	protein coding gene	Chr4:60758934-60789936 (+)
BALB/cJ	MGP_BALBcJ_G0028330	protein coding gene	Chr4:59295589-59328081 (+)
C3H/HeJ	MGP_C3HHeJ_G0028048	protein coding gene	Chr4:61265578-61299943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028770	protein coding gene	Chr4:63444875-63479181 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026076	protein coding gene	Chr4:56410341-56441936 (+)
CAST/EiJ	MGP_CASTEiJ_G0027484	protein coding gene	Chr4:59198742-59233886 (+)
CBA/J	MGP_CBAJ_G0028015	protein coding gene	Chr4:65641909-65677251 (+)
DBA/2J	MGP_DBA2J_G0028165	protein coding gene	Chr4:58977157-59008700 (+)
FVB/NJ	MGP_FVBNJ_G0028130	protein coding gene	Chr4:58223843-58254916 (+)
LP/J	MGP_LPJ_G0028262	protein coding gene	Chr4:61625860-61656974 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028157	protein coding gene	Chr4:68779356-68813122 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028806	protein coding gene	Chr4:60856467-60890508 (+)
PWK/PhJ	MGP_PWKPhJ_G0027211	protein coding gene	Chr4:57452512-57486435 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027040	protein coding gene	Chr4:58300827-58335003 (+)
WSB/EiJ	MGP_WSBEiJ_G0027564	protein coding gene	Chr4:60840345-60873715 (+)

Human Ortholog

SLC31A1, solute carrier family 31 member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC31A1, solute carrier family 31 member 1
Synonyms

COPT1, CTR1, NSCT
Links

HGNC:11016

NCBI Gene ID: 1317

neXtProt AC: NX_O15431

UniProt: O15431
Chr Location

9q32; chr9:113221544-113264492 (+) GRCh38

MGI Vertebrate Homology

Slc31a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC31A1
Gene Tree

Slc31a1

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Phenotype Summary

33 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

70
Endonuclease-mediated

4
Gene trapped

60
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis. Mice heterozygous for a null allele exhibit decreased copper levels in the blood and several organs.

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All GO Annotations

53
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

981
Tissues

137
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc31a1

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All Sequences

53
RefSeq

4
UniProt

3
CCDS

CCDS18237.1

Ensembl

ENSMUSG00000066150 (Evidence)
NCBI Gene

20529

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066150	Ensembl Gene Model \| MGI Sequence Detail	31043	C57BL/6J	± kb
transcript	ENSMUST00000084526	Ensembl \| MGI Sequence Detail	3718	Not Applicable
polypeptide	ENSMUSP00000081574	Ensembl \| MGI Sequence Detail	196	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015083 high affinity copper uptake protein 1

(term hierarchy)
InterPro Domains

IPR007274 Ctr copper transporter
GlyGen

Q8K211 2 sites

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All nucleic 23

Genomic 1

cDNA 19

Primer pair 2

Other 1

Microarray probesets 5

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MGI:1925416, MGI:2140357, MGI:2140433

Summaries

All 72

Developmental Gene Expression 7

Gene Ontology 17

Phenotypes 26
Earliest

J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
Latest

J:346176 Haberkiewicz O, et al., Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease. Int J Mol Sci. 2022 Sep 28;23(19)

TSS for Slc31a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37483	Chr4:62278422-62278464 (+)	-521 bp
Tssr37484	Chr4:62278932-62278995 (+)	0 bp
Tssr37485	Chr4:62279819-62279824 (+)	858 bp
Tssr37486	Chr4:62298252-62298254 (+)	19,289 bp
Tssr37487	Chr4:62306831-62306861 (+)	27,882 bp
Tssr37488	Chr4:62306960-62306981 (+)	28,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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