Hs3st3a1 MGI Mouse Gene Detail - MGI:1333861 - heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

Symbol

Hs3st3a1
Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Synonyms

3Ost3a

Feature Type

protein coding gene
IDs

MGI:1333861
NCBI Gene: 15478
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:64326158-64413667 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 40.24 cM
Mapping Data

2 experiments

SNPs within 2kb

2658 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333861	protein coding gene	Chr11:64326158-64413667 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018472	protein coding gene	Chr11:64601512-64694049 (+)
A/J	MGP_AJ_G0018441	protein coding gene	Chr11:62204461-62290479 (+)
AKR/J	MGP_AKRJ_G0018410	protein coding gene	Chr11:64105741-64194274 (+)
BALB/cJ	MGP_BALBcJ_G0018412	protein coding gene	Chr11:62458085-62542896 (+)
C3H/HeJ	MGP_C3HHeJ_G0018225	protein coding gene	Chr11:64058887-64146595 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018864	protein coding gene	Chr11:66573471-66670214 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016508	protein coding gene	Chr11:59229941-59316674 (+)
CAST/EiJ	MGP_CASTEiJ_G0017781	protein coding gene	Chr11:64265242-64368086 (+)
CBA/J	MGP_CBAJ_G0018199	protein coding gene	Chr11:69474689-69574772 (+)
DBA/2J	MGP_DBA2J_G0018308	protein coding gene	Chr11:61742432-61831102 (+)
FVB/NJ	MGP_FVBNJ_G0018298	protein coding gene	Chr11:61394105-61482643 (+)
LP/J	MGP_LPJ_G0018380	protein coding gene	Chr11:65132254-65230435 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018322	protein coding gene	Chr11:70394757-70490569 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018905	protein coding gene	Chr11:64261827-64350764 (+)
PWK/PhJ	MGP_PWKPhJ_G0017555	protein coding gene	Chr11:62360000-62448648 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017345	protein coding gene	Chr11:64134405-64230145 (+)
WSB/EiJ	MGP_WSBEiJ_G0017834	protein coding gene	Chr11:63888603-63981376 (+)

Human Ortholog

HS3ST3A1, heparan sulfate-glucosamine 3-sulfotransferase 3A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HS3ST3A1, heparan sulfate-glucosamine 3-sulfotransferase 3A1
Synonyms

3-OST-3A, 3OST3A1
Links

HGNC:5196

NCBI Gene ID: 9955

neXtProt AC: NX_Q9Y663

UniProt: Q9Y663
Chr Location

17p12; chr17:13494032-13601929 (-) GRCh38

MGI Vertebrate Homology

Hs3st3a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HS3ST3A1
Gene Tree

Hs3st3a1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Hs3st3a1
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

127
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HS3ST3A1

Xenbase hs3st3a1

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All Sequences

42
RefSeq

6
UniProt

2
CCDS

CCDS24840.1

Ensembl

ENSMUSG00000047759 (Evidence)
NCBI Gene

15478

			Length	Strain/Species	Flank
genomic	15478	NCBI Gene Model \| MGI Sequence Detail	87510	C57BL/6J	± kb
transcript	NM_178870	RefSeq \| MGI Sequence Detail	3933	ZRU/MplStud
polypeptide	Q8BKN6	UniProt \| EBI \| MGI Sequence Detail	393	Not Applicable

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UniProt

2 Sequences
EC

2.8.2.-, 2.8.2.23
InterPro Domains

IPR037359 Heparan sulfate sulfotransferase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000863 Sulfotransferase domain
GlyGen

Q8BKN6 2 sites

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All nucleic 12

cDNA 11

Other 1

Microarray probesets 7

Summaries

All 37

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Hs3st3a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102119	Chr11:64326141-64326165 (+)	-5 bp
Tssr102120	Chr11:64329352-64329357 (+)	3,197 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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