Pde3b MGI Mouse Gene Detail - MGI:1333863 - phosphodiesterase 3B, cGMP-inhibited

Symbol

Pde3b
Name

phosphodiesterase 3B, cGMP-inhibited
Synonyms

9830102A01Rik

Feature Type

protein coding gene
IDs

MGI:1333863
NCBI Gene: 18576
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:114014388-114137173 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 59.46 cM
Mapping Data

3 experiments

SNPs within 2kb

2801 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333863	protein coding gene	Chr7:114014388-114138486 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032882	protein coding gene	Chr7:118079450-118209269 (+)
A/J	MGP_AJ_G0032865	protein coding gene	Chr7:115126024-115253432 (+)
AKR/J	MGP_AKRJ_G0032797	protein coding gene	Chr7:118037378-118165026 (+)
BALB/cJ	MGP_BALBcJ_G0032870	protein coding gene	Chr7:114826773-114951072 (+)
C3H/HeJ	MGP_C3HHeJ_G0032580	protein coding gene	Chr7:118005351-118132943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033376	protein coding gene	Chr7:122827817-122959650 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030348	protein coding gene	Chr7:116650875-116774372 (+)
CAST/EiJ	MGP_CASTEiJ_G0031908	protein coding gene	Chr7:109637580-109777024 (+)
CBA/J	MGP_CBAJ_G0032553	protein coding gene	Chr7:126921829-127059298 (+)
DBA/2J	MGP_DBA2J_G0032705	protein coding gene	Chr7:113175434-113298504 (+)
FVB/NJ	MGP_FVBNJ_G0032658	protein coding gene	Chr7:113036682-113164944 (+)
LP/J	MGP_LPJ_G0032799	protein coding gene	Chr7:119593079-119730880 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032690	protein coding gene	Chr7:128491473-128643174 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033396	protein coding gene	Chr7:117004366-117135327 (+)
PWK/PhJ	MGP_PWKPhJ_G0031616	protein coding gene	Chr7:106042271-106171540 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031463	protein coding gene	Chr7:103741595-103877793 (+)
WSB/EiJ	MGP_WSBEiJ_G0032021	protein coding gene	Chr7:117877818-118006940 (+)

Human Ortholog

PDE3B, phosphodiesterase 3B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE3B, phosphodiesterase 3B
Synonyms

cGIPDE1, HcGIP1
Links

HGNC:8779

NCBI Gene ID: 5140

neXtProt AC: NX_Q13370

UniProt: Q13370
Chr Location

11p15.2

MGI Vertebrate Homology

Pde3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE3B
Gene Tree

Pde3b

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Pde3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutants show abnormalities in glycerol and fatty acid levels, along with changes in adipocyte morphology and decreased body fat percentage.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

116
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde3b

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All Sequences

49
RefSeq

6
UniProt

3
CCDS

CCDS21760.1

Ensembl

ENSMUSG00000030671 (Evidence)
NCBI Gene

18576

			Length	Strain/Species	Flank
genomic	18576	NCBI Gene Model \| MGI Sequence Detail	122786	C57BL/6J	± kb
transcript	NM_011055	RefSeq \| MGI Sequence Detail	5314	ZRU/MplStud
polypeptide	Q61409	UniProt \| EBI \| MGI Sequence Detail	1100	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012471 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

(term hierarchy)
EC

3.1.4.-, 3.1.4.17
InterPro Domains

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR003607 HD/PDEase domain

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 5

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MGI:2142046, MGI:2441760

Summaries

All 78

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 25
Earliest

J:36022 Lobbert RW, et al., Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1. Genomics. 1996 Oct 15;37(2):211-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pde3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68644	Chr7:114014440-114014502 (+)	83 bp
Tssr68645	Chr7:114014507-114014532 (+)	132 bp
Tssr68646	Chr7:114014612-114014619 (+)	228 bp
Tssr68647	Chr7:114015940-114015954 (+)	1,559 bp
Tssr68648	Chr7:114081941-114081951 (+)	67,558 bp
Tssr68649	Chr7:114093798-114093811 (+)	79,417 bp
Tssr68650	Chr7:114101658-114101664 (+)	87,273 bp
Tssr68651	Chr7:114136025-114136045 (+)	121,647 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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