Kcnmb1 MGI Mouse Gene Detail - MGI:1334203 - potassium large conductance calcium-activated channel, subfamily M, beta member 1

Symbol

Kcnmb1
Name

potassium large conductance calcium-activated channel, subfamily M, beta member 1
Synonyms

BKbeta1, BK channel beta subunit

Feature Type

protein coding gene
IDs

MGI:1334203
NCBI Gene: 16533
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:33913013-33923641 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 19.32 cM
Mapping Data

2 experiments

SNPs within 2kb

500 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1334203	protein coding gene	Chr11:33912955-33923641 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018148	protein coding gene	Chr11:32295797-32306413 (+)
A/J	MGP_AJ_G0018121	protein coding gene	Chr11:31066602-31077244 (+)
AKR/J	MGP_AKRJ_G0018085	protein coding gene	Chr11:32030184-32040815 (+)
BALB/cJ	MGP_BALBcJ_G0018090	protein coding gene	Chr11:31246137-31256747 (+)
C3H/HeJ	MGP_C3HHeJ_G0017903	protein coding gene	Chr11:31980921-31991533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018544	protein coding gene	Chr11:33329522-33340162 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016199	protein coding gene	Chr11:29551875-29562864 (+)
CAST/EiJ	MGP_CASTEiJ_G0017467	protein coding gene	Chr11:32089069-32099747 (+)
CBA/J	MGP_CBAJ_G0017876	protein coding gene	Chr11:34985941-34996546 (+)
DBA/2J	MGP_DBA2J_G0017986	protein coding gene	Chr11:30834155-30844761 (+)
FVB/NJ	MGP_FVBNJ_G0017980	protein coding gene	Chr11:30656848-30667534 (+)
LP/J	MGP_LPJ_G0018058	protein coding gene	Chr11:32567953-32578595 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018004	protein coding gene	Chr11:35883375-35894013 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018583	protein coding gene	Chr11:32188233-32198883 (+)
PWK/PhJ	MGP_PWKPhJ_G0017248	protein coding gene	Chr11:31024725-31035491 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017040	protein coding gene	Chr11:31920989-31932216 (+)
WSB/EiJ	MGP_WSBEiJ_G0017516	protein coding gene	Chr11:31821020-31831610 (+)

Human Ortholog

KCNMB1, potassium calcium-activated channel subfamily M regulatory beta subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNMB1, potassium calcium-activated channel subfamily M regulatory beta subunit 1
Synonyms

BKbeta1, hbeta1, hslo-beta, K(VCA)beta, k(VCA)beta-1, SLO-BETA, slo-beta-1
Links

HGNC:6285

NCBI Gene ID: 3779

neXtProt AC: NX_Q16558

UniProt: Q16558
Chr Location

5q35.1; chr5:170374671-170389634 (-) GRCh38

MGI Vertebrate Homology

Kcnmb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNMB1
Gene Tree

Kcnmb1

Diseases

1 with human KCNMB1 associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

6
Genomic Mutations

1 involving Kcnmb1
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in increased blood pressure, and impaired motor coordination and cerebellar function.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

29
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnmb1

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS24538.1

Ensembl

ENSMUSG00000020155 (Evidence)
NCBI Gene

16533

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020155	Ensembl Gene Model \| MGI Sequence Detail	10629	C57BL/6J	± kb
transcript	ENSMUST00000020362	Ensembl \| MGI Sequence Detail	4191	Not Applicable
polypeptide	ENSMUSP00000020362	Ensembl \| MGI Sequence Detail	191	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009266 calcium-activated potassium channel subunit beta-1

(term hierarchy)
InterPro Domains

IPR003930 Potassium channel, calcium-activated, BK, beta subunit
GlyGen

Q8CAE3 2 sites

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All nucleic 16

Genomic 1

cDNA 14

Primer pair 1

Microarray probesets 5

Summaries

All 69

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 35
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:342429 North KC, et al., Progesterone activation of beta(1)-containing BK channels involves two binding sites. Nat Commun. 2023 Nov 9;14(1):7248

TSS for Kcnmb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100887	Chr11:33913206-33913243 (+)	212 bp
Tssr100888	Chr11:33913281-33913297 (+)	276 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24