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Zfpm2 Gene Detail
Summary
  • Symbol
    Zfpm2
  • Name
    zinc finger protein, multitype 2
  • Synonyms
    B330005D23Rik, FOG-2, FOG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334444
    NCBI Gene: 22762
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:40518438-40967988 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.74 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11154 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334444
 protein coding gene Chr15:40518431-40967988 (+)
129S1/SvImJ ENSMUSG00200025605
 protein coding gene Chr15:37413031-37915603 (+)
A/J ENSMUSG00195032877
 protein coding gene Chr15:37398531-37908580 (+)
AKR/J ENSMUSG00220027454
 protein coding gene Chr15:37285437-37788925 (+)
BALB/cJ ENSMUSG00180030138
 protein coding gene Chr15:37376749-37886765 (+)
C3H/HeJ ENSMUSG00175024869
 protein coding gene Chr15:37538095-38043999 (+)
C57BL/6NJ ENSMUSG00215011725
 protein coding gene Chr15:37371250-37881299 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019763
 protein coding gene Chr15:35331741-35769613 (+)
CAST/EiJ ENSTCUG00005010020
 protein coding gene Chr15:37440540-37890022 (+)
CBA/J ENSMUSG00210017707
 protein coding gene Chr15:37492164-38002197 (+)
DBA/2J ENSMUSG00185033625
 protein coding gene Chr15:37472998-37983024 (+)
FVB/NJ ENSMUSG00205027550
 protein coding gene Chr15:37328247-37831703 (+)
JF1/MsJ ENSUMUG00000031692
 protein coding gene Chr15:37372682-37814562 (+)
LP/J ENSMUSG00230010989
 protein coding gene Chr15:40795608-41298121 (+)
NOD/ShiLtJ ENSMUSG00190023874
 protein coding gene Chr15:37405903-37908759 (+)
NZO/HlLtJ ENSMUSG00225037811
 protein coding gene Chr15:41151272-41661264 (+)
PWK/PhJ ENSLUMG00010029339
 protein coding gene Chr15:37539224-37985125 (+)
SPRET/EiJ ENSMSPG00010012405
 protein coding gene Chr15:38314069-38766629 (+)
WSB/EiJ ENSIUOG00005029877
 protein coding gene Chr15:37443430-37944427 (+)



Homology
more
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Synonyms
    DIH3, FOG2, hFOG-2, PRDM19, SRXY9, ZC2HC11B, ZNF89B
  • Links
    NCBI Gene ID: 23414
    UniProt: Q8WW38

  • Chr Location
    8q23.1; chr8:104590733-105804539 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Zfpm2 mouse models; 4 with human ZFPM2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 6 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    9 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    158
  • cDNA Data
    30
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ±  kb
    transcript NM_011766 RefSeq | MGI Sequence Detail 4974 ZRU/MplStud  
    polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 30
      Primer pair 11
      Other 8
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444606
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 76
      Diseases 4
      Gene Ontology 20
      Phenotypes 41
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:365688 Broman MT, et al., A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 9;149(15):1205-1230
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory