Cpne6 MGI Mouse Gene Detail - MGI:1334445

Symbol

Cpne6
Name

copine VI
Synonyms

neuronal copine

Feature Type

protein coding gene
IDs

MGI:1334445
NCBI Gene: 12891
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:55747902-55754888 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

1 experiment

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1334445	protein coding gene	Chr14:55747902-55754892 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021345	protein coding gene	Chr14:49539355-49546339 (+)
A/J	MGP_AJ_G0021304	protein coding gene	Chr14:48555746-48562728 (+)
AKR/J	MGP_AKRJ_G0021280	protein coding gene	Chr14:50302481-50309463 (+)
BALB/cJ	MGP_BALBcJ_G0021308	protein coding gene	Chr14:48501068-48508078 (+)
C3H/HeJ	MGP_C3HHeJ_G0021088	protein coding gene	Chr14:49987346-49994332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021746	protein coding gene	Chr14:52030324-52037310 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019293	protein coding gene	Chr14:46933050-46940151 (+)
CAST/EiJ	MGP_CASTEiJ_G0020607	protein coding gene	Chr14:46247060-46254054 (+)
CBA/J	MGP_CBAJ_G0021055	protein coding gene	Chr14:53589232-53596214 (+)
DBA/2J	MGP_DBA2J_G0021176	protein coding gene	Chr14:48275902-48282921 (+)
FVB/NJ	MGP_FVBNJ_G0021158	protein coding gene	Chr14:47731783-47739262 (+)
LP/J	MGP_LPJ_G0021250	protein coding gene	Chr14:50579054-50586058 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021182	protein coding gene	Chr14:52951222-52958244 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021773	protein coding gene	Chr14:49485949-49492933 (+)
PWK/PhJ	MGP_PWKPhJ_G0020354	protein coding gene	Chr14:44811221-44818321 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020182	protein coding gene	Chr14:45478088-45485132 (+)
WSB/EiJ	MGP_WSBEiJ_G0020660	protein coding gene	Chr14:49767383-49774363 (+)

Human Ortholog

CPNE6, copine 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPNE6, copine 6
Synonyms

copine-6
Links

HGNC:2319

NCBI Gene ID: 9362

neXtProt AC: NX_O95741

UniProt: O95741
Chr Location

14q11.2; chr14:24070837-24078100 (+) GRCh38

MGI Vertebrate Homology

Cpne6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CPNE6
Gene Tree

Cpne6

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Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

1 involving Cpne6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired synaptic plasticity, reduced long term potentiation, and deficits in hippocampus-dependent learning and memory.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

13
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

57
RefSeq

8
UniProt

4
CCDS

CCDS27112.1, CCDS49493.1

Ensembl

ENSMUSG00000022212 (Evidence)
NCBI Gene

12891

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022212	Ensembl Gene Model \| MGI Sequence Detail	6987	C57BL/6J	± kb
transcript	ENSMUST00000171643	Ensembl \| MGI Sequence Detail	2016	Not Applicable
polypeptide	ENSMUSP00000128555	Ensembl \| MGI Sequence Detail	557	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005821 copine-6

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR045052 Copine

IPR037768 Copine, C2B domain

IPR010734 Copine, C-terminal

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q9Z140 1 site, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:2145764, MGI:2145848

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 7
Earliest

J:49331 Nakayama T, et al., N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. FEBS Lett. 1998 May 22;428(1-2):80-4
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cpne6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4429	Chr14:55747926-55747942 (+)	32 bp
Tssr4430	Chr14:55747952-55747971 (+)	60 bp
Tssr125762	Chr14:55748050-55748088 (+)	167 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24