Elf5 MGI Mouse Gene Detail - MGI:1335079

Symbol

Elf5
Name

E74-like factor 5
Synonyms

ESE-2

Feature Type

protein coding gene
IDs

MGI:1335079
NCBI Gene: 13711
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:103242443-103281334 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.43 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

1096 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1335079	protein coding gene	Chr2:103242033-103281334 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026203	protein coding gene	Chr2:105393412-105433874 (+)
A/J	MGP_AJ_G0026164	protein coding gene	Chr2:101041557-101081699 (+)
AKR/J	MGP_AKRJ_G0026145	protein coding gene	Chr2:103780147-103823845 (+)
BALB/cJ	MGP_BALBcJ_G0026173	protein coding gene	Chr2:101328254-101368828 (+)
C3H/HeJ	MGP_C3HHeJ_G0025924	protein coding gene	Chr2:104134593-104173193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026624	protein coding gene	Chr2:108931287-108973874 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024015	protein coding gene	Chr2:96720686-96761816 (+)
CAST/EiJ	MGP_CASTEiJ_G0025389	protein coding gene	Chr2:104602523-104646441 (+)
CBA/J	MGP_CBAJ_G0025902	protein coding gene	Chr2:112657042-112699409 (+)
DBA/2J	MGP_DBA2J_G0026038	protein coding gene	Chr2:100608282-100647412 (+)
FVB/NJ	MGP_FVBNJ_G0026001	protein coding gene	Chr2:99607904-99648423 (+)
LP/J	MGP_LPJ_G0026142	protein coding gene	Chr2:105528546-105568851 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026027	protein coding gene	Chr2:116574979-116622973 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026678	protein coding gene	Chr2:104001441-104040368 (+)
PWK/PhJ	MGP_PWKPhJ_G0025124	protein coding gene	Chr2:100113030-100158293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024925	protein coding gene	Chr2:103219935-103260886 (+)
WSB/EiJ	MGP_WSBEiJ_G0025456	protein coding gene	Chr2:104705148-104746550 (+)

Human Ortholog

ELF5, E74 like ETS transcription factor 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELF5, E74 like ETS transcription factor 5
Synonyms

ESE2
Links

HGNC:3320

NCBI Gene ID: 2001

neXtProt AC: NX_Q9UKW6

UniProt: Q9UKW6
Chr Location

11p13; chr11:34478791-34525193 (-) GRCh38

MGI Vertebrate Homology

Elf5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ELF5
Gene Tree

Elf5

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Phenotype Summary

20 phenotypes from 4 alleles in 7 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Elf5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice display embryonic lethality. Embryos homozygous for one null allele failed to develop extraembryonic ectoderm, did not maintain trophoblast stem cells, and had abnormal or absent mesoderm. Mice heterozygous for another allele had impaired lactation and mammary gland development.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

985
Tissues

148
cDNA Data

84
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

6
UniProt

5
CCDS

CCDS16477.1

Ensembl

ENSMUSG00000027186 (Evidence)
NCBI Gene

13711

			Length	Strain/Species	Flank
genomic	13711	NCBI Gene Model \| MGI Sequence Detail	38892	C57BL/6J	± kb
transcript	NM_010125	RefSeq \| MGI Sequence Detail	2216	C57BL/6
polypeptide	Q8VDK3	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007024 ETS-related transcription factor Elf-5

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR003118 Pointed domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 99

cDNA 85

Primer pair 12

Other 2

Microarray probesets 4

Summaries

All 86

Developmental Gene Expression 43

Gene Ontology 8

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346388 Kim U, et al., DeltaNp63 regulates MDSC survival and metabolism in triple-negative breast cancer. iScience. 2024 Apr 19;27(4):109366

TSS for Elf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19148	Chr2:103242027-103242041 (+)	-409 bp
Tssr583	Chr2:103242094-103242095 (+)	-348 bp
Tssr19149	Chr2:103242105-103242115 (+)	-333 bp
Tssr19150	Chr2:103242419-103242444 (+)	-11 bp
Tssr19151	Chr2:103254401-103254421 (+)	11,968 bp
Tssr19152	Chr2:103254433-103254456 (+)	12,002 bp
Tssr19153	Chr2:103254465-103254480 (+)	12,030 bp
Tssr19154	Chr2:103255140-103255151 (+)	12,703 bp
Tssr19155	Chr2:103255165-103255174 (+)	12,727 bp
Tssr19156	Chr2:103269735-103269738 (+)	27,294 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24