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Fem1b Gene Detail
Summary
  • Symbol
    Fem1b
  • Name
    fem 1 homolog b
  • Synonyms
    mKIAA0396
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335087
    NCBI Gene: 14155
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62699106-62718930 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335087
 protein coding gene Chr9:62699103-62719216 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034923
 protein coding gene Chr9:62350612-62374757 (-)
A/J MGP_AJ_G0034903
 protein coding gene Chr9:60293159-60314238 (-)
AKR/J MGP_AKRJ_G0034833
 protein coding gene Chr9:61694675-61721631 (-)
BALB/cJ MGP_BALBcJ_G0034896
 protein coding gene Chr9:60021739-60042366 (-)
C3H/HeJ MGP_C3HHeJ_G0034606
 protein coding gene Chr9:62207964-62228589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035415
 protein coding gene Chr9:64070261-64092817 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032326
 protein coding gene Chr9:59952758-59971893 (-)
CAST/EiJ MGP_CASTEiJ_G0033927
 protein coding gene Chr9:62344821-62369477 (-)
CBA/J MGP_CBAJ_G0034577
 protein coding gene Chr9:66272659-66298015 (-)
DBA/2J MGP_DBA2J_G0034736
 protein coding gene Chr9:60092047-60113169 (-)
FVB/NJ MGP_FVBNJ_G0034678
 protein coding gene Chr9:59375564-59397512 (-)
LP/J MGP_LPJ_G0034819
 protein coding gene Chr9:62644699-62665994 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034721
 protein coding gene Chr9:67625640-67648024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035437
 protein coding gene Chr9:61771399-61797438 (-)
PWK/PhJ MGP_PWKPhJ_G0033631
 protein coding gene Chr9:60214249-60235903 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033464
 protein coding gene Chr9:62062702-62083008 (-)
WSB/EiJ MGP_WSBEiJ_G0034040
 protein coding gene Chr9:61686452-61707702 (-)



Homology
more
  • Human Ortholog
    FEM1B, fem-1 homolog B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEM1B, fem-1 homolog B
  • Synonyms
    F1AA, F1A-ALPHA, FEM1-beta
  • Links
    NCBI Gene ID: 10116
    neXtProt AC: NX_Q9UK73
    UniProt: Q9UK73

  • Chr Location
    15q23; chr15:68277745-68295862 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fem1b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display abnormal glucose tolerance due to defective glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    80
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14155 NCBI Gene Model | MGI Sequence Detail 19825 C57BL/6J ±  kb
    transcript NM_010193 RefSeq | MGI Sequence Detail 6505 ZRU/MplStud  
    polypeptide Q9Z2G0 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 6
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
    • Latest
      J:338230 Manford AG, et al., Structural basis and regulation of the reductive stress response. Cell. 2021 Oct 14;184(21):5375-5390.e16
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory