Zbtb7a MGI Mouse Gene Detail - MGI:1335091 - zinc finger and BTB domain containing 7a

Symbol

Zbtb7a
Name

zinc finger and BTB domain containing 7a
Synonyms

9030619K07Rik, 9130006G12Rik, FBI-1, Leukemia/lymphoma Related Factor, Lrf, Pokemon, Zbtb7

Feature Type

protein coding gene
IDs

MGI:1335091
NCBI Gene: 16969
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:80971113-80988056 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband B5.3
Mapping Data

3 experiments

SNPs within 2kb

254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1335091	protein coding gene	Chr10:80971054-80988829 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017537	protein coding gene	Chr10:81827188-81844980 (+)
A/J	MGP_AJ_G0017515	protein coding gene	Chr10:78931871-78949693 (+)
AKR/J	MGP_AKRJ_G0017476	protein coding gene	Chr10:81104190-81121956 (+)
BALB/cJ	MGP_BALBcJ_G0017477	protein coding gene	Chr10:79147244-79165304 (+)
C3H/HeJ	MGP_C3HHeJ_G0017300	protein coding gene	Chr10:81185337-81204546 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017931	protein coding gene	Chr10:84628897-84647183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015620	protein coding gene	Chr10:75133920-75152068 (+)
CAST/EiJ	MGP_CASTEiJ_G0016867	protein coding gene	Chr10:81424425-81442201 (+)
CBA/J	MGP_CBAJ_G0017272	protein coding gene	Chr10:87930796-87948764 (+)
DBA/2J	MGP_DBA2J_G0017378	protein coding gene	Chr10:78125220-78145586 (+)
FVB/NJ	MGP_FVBNJ_G0017372	protein coding gene	Chr10:77371597-77392475 (+)
LP/J	MGP_LPJ_G0017449	protein coding gene	Chr10:82273516-82292017 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017398	protein coding gene	Chr10:89798083-89815903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017972	protein coding gene	Chr10:81091056-81109867 (+)
PWK/PhJ	MGP_PWKPhJ_G0016648	protein coding gene	Chr10:78030388-78048676 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016438	protein coding gene	Chr10:80047286-80066437 (+)
WSB/EiJ	MGP_WSBEiJ_G0016927	protein coding gene	Chr10:81129578-81147398 (+)

Human Ortholog

ZBTB7A, zinc finger and BTB domain containing 7A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB7A, zinc finger and BTB domain containing 7A
Synonyms

FBI-1, FBI1, LRF, MNDLFH, pokemon, TIP21, ZBTB7, ZNF857A
Links

HGNC:18078

NCBI Gene ID: 51341

neXtProt AC: NX_O95365

UniProt: O95365
Chr Location

19p13.3; chr19:4043303-4066899 (-) GRCh38

MGI Vertebrate Homology

Zbtb7a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB7A
Gene Tree

Zbtb7a

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

74
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

66
Targeted

5
Genomic Mutations

1 involving Zbtb7a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

64 strains or lines available

Mice homozygous for a knock-out allele die around E16.5 due to anemia and exhibit a cell autonomous defect in early B cell development.

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All GO Annotations

68
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

94
cDNA Data

17
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

71
RefSeq

16
UniProt

5
CCDS

CCDS35991.1

Ensembl

ENSMUSG00000035011 (Evidence)
NCBI Gene

16969

			Length	Strain/Species	Flank
genomic	16969	NCBI Gene Model \| MGI Sequence Detail	16944	C57BL/6J	± kb
transcript	NM_001404864	RefSeq \| MGI Sequence Detail	5974	C57BL/6
polypeptide	O88939	UniProt \| EBI \| MGI Sequence Detail	569	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017592 zinc finger and BTB domain-containing protein 7A

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR050457 Zinc finger and BTB domain-containing

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 21

Genomic 1

cDNA 19

Primer pair 1

Microarray probesets 8

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MGI:1918856, MGI:2143616

Summaries

All 75

Developmental Gene Expression 8

Gene Ontology 12

Phenotypes 34
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:335582 Yuan W, et al., Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex. Nat Neurosci. 2022 Aug;25(8):1049-1058

TSS for Zbtb7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94677	Chr10:80970298-80970329 (+)	-799 bp
Tssr94678	Chr10:80971107-80971125 (+)	3 bp
Tssr94679	Chr10:80971298-80971325 (+)	199 bp
Tssr94680	Chr10:80972057-80972101 (+)	966 bp
Tssr94681	Chr10:80972165-80972216 (+)	1,078 bp
Tssr94682	Chr10:80972337-80972350 (+)	1,231 bp
Tssr94683	Chr10:80972368-80972442 (+)	1,292 bp
Tssr94684	Chr10:80973554-80973578 (+)	2,453 bp
Tssr94685	Chr10:80973814-80973826 (+)	2,707 bp
Tssr94686	Chr10:80973838-80973855 (+)	2,734 bp
Tssr94687	Chr10:80975339-80975346 (+)	4,230 bp
Tssr94688	Chr10:80984245-80984261 (+)	13,140 bp
Tssr94689	Chr10:80985087-80985131 (+)	13,996 bp
Tssr94690	Chr10:80986535-80986572 (+)	15,441 bp
Tssr94691	Chr10:80986835-80986847 (+)	15,728 bp
Tssr94692	Chr10:80987294-80987308 (+)	16,188 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24