Minpp1 MGI Mouse Gene Detail - MGI:1336159 - multiple inositol polyphosphate histidine phosphatase 1

Symbol

Minpp1
Name

multiple inositol polyphosphate histidine phosphatase 1

Feature Type

protein coding gene
IDs

MGI:1336159
NCBI Gene: 17330
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:32463169-32492764 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 27.25 cM
Mapping Data

3 experiments

SNPs within 2kb

892 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336159	protein coding gene	Chr19:32463169-32492770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025040	protein coding gene	Chr19:31119090-31149718 (+)
A/J	MGP_AJ_G0025017	protein coding gene	Chr19:29569281-29601240 (+)
AKR/J	MGP_AKRJ_G0024985	protein coding gene	Chr19:30603318-30634262 (+)
BALB/cJ	MGP_BALBcJ_G0025016	protein coding gene	Chr19:29621833-29651179 (+)
C3H/HeJ	MGP_C3HHeJ_G0024772	protein coding gene	Chr19:30596306-30624628 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025457	protein coding gene	Chr19:31982509-32015368 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022876	protein coding gene	Chr19:29474637-29506522 (+)
CAST/EiJ	MGP_CASTEiJ_G0024243	protein coding gene	Chr19:30498894-30529401 (+)
CBA/J	MGP_CBAJ_G0024750	protein coding gene	Chr19:33471745-33507108 (+)
DBA/2J	MGP_DBA2J_G0024882	protein coding gene	Chr19:29493502-29522636 (+)
FVB/NJ	MGP_FVBNJ_G0024844	protein coding gene	Chr19:29317925-29347056 (+)
LP/J	MGP_LPJ_G0024967	protein coding gene	Chr19:31121044-31150068 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024871	protein coding gene	Chr19:33330547-33359559 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025512	protein coding gene	Chr19:30653171-30685156 (+)
PWK/PhJ	MGP_PWKPhJ_G0023991	protein coding gene	Chr19:29188977-29217947 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023795	protein coding gene	Chr19:29987521-30014734 (+)
WSB/EiJ	MGP_WSBEiJ_G0024309	protein coding gene	Chr19:30690198-30720629 (+)

Human Ortholog

MINPP1, multiple inositol-polyphosphate phosphatase 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MINPP1, multiple inositol-polyphosphate phosphatase 1
Synonyms

HIPER1, MINPP2, MIPP, PCH16
Links

HGNC:7102

NCBI Gene ID: 9562

neXtProt AC: NX_Q9UNW1

UniProt: Q9UNW1
Chr Location

10q23.2; chr10:87504875-87553461 (+) GRCh38

MGI Vertebrate Homology

Minpp1 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: MINPP1
Protein SuperFamily

Acid_phosphatase
Gene Tree

Minpp1

Diseases

2 with human MINPP1 associations

				Human Disease	Mouse Models
				papillary thyroid carcinoma IDs papillary thyroid carcinoma DOID:3969 MESH:D000077273 NCI:C4035 OMIM:188550 UMLS_CUI:C0238463
				pontocerebellar hypoplasia type 16 IDs pontocerebellar hypoplasia type 16 DOID:0112333 OMIM:619527

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation exhibit no discernable phenotype. Another null allele shows a 10% decrease in brain weight due to reduced cortical thickness and decreased intracellular free calcium levels in E14.5 neural progenitors.

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All GO Annotations

32
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

100
cDNA Data

61
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase minpp1

ZFIN minpp1b

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS29751.1

Ensembl

ENSMUSG00000024896 (Evidence)
NCBI Gene

17330

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024896	Ensembl Gene Model \| MGI Sequence Detail	29596	C57BL/6J	± kb
transcript	ENSMUST00000025827	Ensembl \| MGI Sequence Detail	2613	Not Applicable
polypeptide	ENSMUSP00000025827	Ensembl \| MGI Sequence Detail	481	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010416 multiple inositol polyphosphate phosphatase 1

(term hierarchy)
EC

3.1.3.62, 3.1.3.80
InterPro Domains

IPR016274 Histidine acid phosphatase, eukaryotic

IPR029033 Histidine phosphatase superfamily

IPR000560 Histidine phosphatase superfamily, clade-2
GlyGen

Q9Z2L6 2 sites, 8 N-linked glycans (2 sites)

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All nucleic 66

Genomic 1

cDNA 64

Primer pair 1

Microarray probesets 6

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MGI:2147435

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 7
Earliest

J:54008 Chi H, et al., Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics. 1999 Mar 15;56(3):324-36
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Minpp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155959	Chr19:32463125-32463135 (+)	-39 bp
Tssr155960	Chr19:32463151-32463174 (+)	-6 bp
Tssr155961	Chr19:32463187-32463202 (+)	26 bp
Tssr155963	Chr19:32468672-32468693 (+)	5,514 bp
Tssr155964	Chr19:32468701-32468712 (+)	5,538 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24