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Kcnk5 Gene Detail
Summary
  • Symbol
    Kcnk5
  • Name
    potassium channel, subfamily K, member 5
  • Synonyms
    TASK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336175
    NCBI Gene: 16529
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20190125-20231850 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.43 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1034 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336175
 protein coding gene Chr14:20190125-20231877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021028
 protein coding gene Chr14:12883855-12925603 (-)
A/J MGP_AJ_G0020977
 protein coding gene Chr14:12591171-12633123 (-)
AKR/J MGP_AKRJ_G0020954
 protein coding gene Chr14:13104172-13145850 (-)
BALB/cJ MGP_BALBcJ_G0020980
 protein coding gene Chr14:12704534-12746256 (-)
C3H/HeJ MGP_C3HHeJ_G0020764
 protein coding gene Chr14:13048186-13090157 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021413
 protein coding gene Chr14:13387219-13429001 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018981
 protein coding gene Chr14:12906955-12949812 (-)
CAST/EiJ MGP_CASTEiJ_G0020288
 protein coding gene Chr14:12804564-12850642 (-)
CBA/J MGP_CBAJ_G0020730
 protein coding gene Chr14:14061381-14103059 (-)
DBA/2J MGP_DBA2J_G0020853
 protein coding gene Chr14:12421924-12463655 (-)
FVB/NJ MGP_FVBNJ_G0020836
 protein coding gene Chr14:12321681-12363731 (-)
LP/J MGP_LPJ_G0020929
 protein coding gene Chr14:13100225-13142192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020862
 protein coding gene Chr14:13845387-13887115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021446
 protein coding gene Chr14:12899219-12940913 (-)
PWK/PhJ MGP_PWKPhJ_G0020037
 protein coding gene Chr14:11972529-12016828 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019859
 protein coding gene Chr14:12670764-12716785 (-)
WSB/EiJ MGP_WSBEiJ_G0020344
 protein coding gene Chr14:12884094-12926727 (-)



Homology
more
  • Human Ortholog
    KCNK5, potassium two pore domain channel subfamily K member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK5, potassium two pore domain channel subfamily K member 5
  • Synonyms
    K2p5.1, KCNK5b, TASK-2, TASK2
  • Links
    NCBI Gene ID: 8645
    neXtProt AC: NX_O95279
    UniProt: O95279

  • Chr Location
    6p21.2; chr6:39188971-39229475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are smaller than normal and display varying amounts of prenatal lethality depending on genetic background. Otherwise, the mice are viable and fertile. Other targeted mice display aberrations in respiratory physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    12
  • cDNA Data
    65
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16529 NCBI Gene Model | MGI Sequence Detail 41726 C57BL/6J ±  kb
    transcript NM_021542 RefSeq | MGI Sequence Detail 3364 C57BL/6  
    polypeptide NP_067517 RefSeq | MGI Sequence Detail 502 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
      6WLV, 6WM0
    • InterPro Domains
      IPR013099 Potassium channel domain
      IPR003280 Two pore domain potassium channel
      IPR003092 Two pore domain potassium channel, TASK family
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 65
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 25
    • Earliest
      J:51616 Reyes R, et al., Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem. 1998 Nov 20;273(47):30863-9
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory