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Prkab2 Gene Detail
Summary
  • Symbol
    Prkab2
  • Name
    protein kinase, AMP-activated, beta 2 non-catalytic subunit
  • Synonyms
    5730553K21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336185
    NCBI Gene: 108097
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97565527-97581128 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    426 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336185
 protein coding gene Chr3:97565509-97581128 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027643
 protein coding gene Chr3:98612235-98627856 (+)
A/J MGP_AJ_G0027605
 protein coding gene Chr3:95457366-95472995 (+)
AKR/J MGP_AKRJ_G0027572
 protein coding gene Chr3:97742170-97757779 (+)
BALB/cJ MGP_BALBcJ_G0027615
 protein coding gene Chr3:95259340-95274965 (+)
C3H/HeJ MGP_C3HHeJ_G0027347
 protein coding gene Chr3:98011311-98026937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028061
 protein coding gene Chr3:102283950-102299628 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025403
 protein coding gene Chr3:91717680-91733329 (+)
CAST/EiJ MGP_CASTEiJ_G0026802
 protein coding gene Chr3:97304965-97320569 (+)
CBA/J MGP_CBAJ_G0027322
 protein coding gene Chr3:105924075-105939696 (+)
DBA/2J MGP_DBA2J_G0027465
 protein coding gene Chr3:94771491-94787112 (+)
FVB/NJ MGP_FVBNJ_G0027434
 protein coding gene Chr3:92761603-92777216 (+)
LP/J MGP_LPJ_G0027570
 protein coding gene Chr3:99871572-99887195 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027460
 protein coding gene Chr3:112018467-112034059 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028115
 protein coding gene Chr3:97367088-97382705 (+)
PWK/PhJ MGP_PWKPhJ_G0026527
 protein coding gene Chr3:94637514-94653224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026349
 protein coding gene Chr3:95640512-95656070 (+)
WSB/EiJ MGP_WSBEiJ_G0026880
 protein coding gene Chr3:97799747-97815360 (+)



Homology
more
  • Human Ortholog
    PRKAB2, protein kinase AMP-activated non-catalytic subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAB2, protein kinase AMP-activated non-catalytic subunit beta 2
  • Links
    NCBI Gene ID: 5565
    neXtProt AC: NX_O43741
    UniProt: O43741

  • Chr Location
    1q21.1; chr1:147155106-147172550 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased exercise endurance, muscle force, muscle and liver glycogen, and skeletal muscle fiber size and increased susceptibility to diet induced obesity and hyperinsulinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    42
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108097 NCBI Gene Model | MGI Sequence Detail 15602 C57BL/6J ±  kb
    transcript NM_182997 RefSeq | MGI Sequence Detail 4278 C57BL/6  
    polypeptide Q6PAM0 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013221 5'-AMP-activated protein kinase subunit beta-2
      (term hierarchy)
    • InterPro Domains
      IPR032640 AMP-activated protein kinase, glycogen-binding domain
      IPR037256 ASC domain superfamily
      IPR006828 Association with the SNF1 complex (ASC) domain
      IPR050827 CRP1/MDG1 DNA-binding & kinase subunit
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
    • GlyGen
      Q6PAM0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1922036, MGI:2139959, MGI:2140024
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 31
    • Earliest
      J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory