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Nxph4 Gene Detail
Summary
  • Symbol
    Nxph4
  • Name
    neurexophilin 4
  • Synonyms
    1110036M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336197
    NCBI Gene: 104080
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127361342-127370428 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336197
 protein coding gene Chr10:127361342-127370428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017826
 protein coding gene Chr10:131145599-131156154 (-)
A/J MGP_AJ_G0017801
 protein coding gene Chr10:125893865-125903010 (-)
AKR/J MGP_AKRJ_G0017764
 protein coding gene Chr10:129608137-129617189 (-)
BALB/cJ MGP_BALBcJ_G0017765
 protein coding gene Chr10:126296685-126306242 (-)
C3H/HeJ MGP_C3HHeJ_G0017589
 protein coding gene Chr10:129760366-129769430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018220
 protein coding gene Chr10:135587756-135598694 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015900
 protein coding gene Chr10:119879996-119889070 (-)
CAST/EiJ MGP_CASTEiJ_G0017149
 protein coding gene Chr10:130418962-130429057 (-)
CBA/J MGP_CBAJ_G0017558
 protein coding gene Chr10:141055389-141064458 (-)
DBA/2J MGP_DBA2J_G0017664
 protein coding gene Chr10:124969148-124978592 (-)
FVB/NJ MGP_FVBNJ_G0017659
 protein coding gene Chr10:123909501-123920063 (-)
LP/J MGP_LPJ_G0017738
 protein coding gene Chr10:131716992-131726062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017687
 protein coding gene Chr10:143750635-143759743 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018260
 protein coding gene Chr10:129675343-129684423 (-)
PWK/PhJ MGP_PWKPhJ_G0016934
 protein coding gene Chr10:125174868-125183954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016726
 protein coding gene Chr10:128716239-128725298 (-)
WSB/EiJ MGP_WSBEiJ_G0017210
 protein coding gene Chr10:129902500-129911553 (-)



Homology
more
  • Human Ortholog
    NXPH4, neurexophilin 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXPH4, neurexophilin 4
  • Synonyms
    NPH4
  • Links
    NCBI Gene ID: 11247
    neXtProt AC: NX_O95158
    UniProt: O95158

  • Chr Location
    12q13.3; chr12:57216794-57226449 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    38
  • cDNA Data
    5
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104080 NCBI Gene Model | MGI Sequence Detail 9087 C57BL/6J ±  kb
    transcript NM_183297 RefSeq | MGI Sequence Detail 1675 C57BL/6  
    polypeptide NP_899120 RefSeq | MGI Sequence Detail 304 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR010450 Neurexophilin
      IPR026845 Neurexophilin/NXPE
    • GlyGen
      G3X9N5 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915952, MGI:2143689
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 12
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:51648 Missler M, et al., Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998 Dec 25;273(52):34716-23
    • Latest
      J:337820 Wang Q, et al., Regional and cell-type-specific afferent and efferent projections of the mouse claustrum. Cell Rep. 2023 Feb 11;42(2):112118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory