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Prdx6b Gene Detail
Summary
  • Symbol
    Prdx6b
  • Name
    peroxiredoxin 6B
  • Synonyms
    1-cysPrx-P1, 4930414C22Rik, Aop2-rs1, Prdx6-ps1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336888
    NCBI Gene: 320769
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:80122816-80125700 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 48.03 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336888
 protein coding gene Chr2:80122814-80125702 (+)
129S1/SvImJ ENSMUSG00200002901
 protein coding gene Chr2:77165399-77168283 (+)
A/J ENSMUSG00195016769
 protein coding gene Chr2:77352921-77355805 (+)
AKR/J ENSMUSG00220001933
 protein coding gene Chr2:77369775-77372659 (+)
BALB/cJ ENSMUSG00180006181
 protein coding gene Chr2:77286014-77288898 (+)
C3H/HeJ ENSMUSG00175010122
 protein coding gene Chr2:77413602-77416486 (+)
C57BL/6NJ ENSMUSG00215014743
 protein coding gene Chr2:77244318-77247202 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023704
 protein coding gene Chr2:74969633-74972685 (+)
CAST/EiJ ENSTCUG00005027367
 protein coding gene Chr2:76747862-76750746 (+)
CBA/J ENSMUSG00210002375
 protein coding gene Chr2:77445923-77448807 (+)
DBA/2J ENSMUSG00185010199
 protein coding gene Chr2:77282268-77285152 (+)
FVB/NJ ENSMUSG00205011452
 protein coding gene Chr2:76629349-76632233 (+)
JF1/MsJ ENSUMUG00000020447
 protein coding gene Chr2:76995299-76998174 (+)
LP/J ENSMUSG00230024580
 protein coding gene Chr2:79087917-79090801 (+)
NOD/ShiLtJ ENSMUSG00190010331
 protein coding gene Chr2:77342215-77345098 (+)
NZO/HlLtJ ENSMUSG00225003127
 protein coding gene Chr2:86835800-86838684 (+)
PWK/PhJ ENSLUMG00010028718
 protein coding gene Chr2:77156840-77159722 (+)
SPRET/EiJ ENSMSPG00010021277
 protein coding gene Chr2:78511680-78514568 (+)
WSB/EiJ ENSIUOG00005010800
 protein coding gene Chr2:78606533-78609416 (-)



Homology
more
  • Human Ortholog
    PRDX6, peroxiredoxin 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDX6, peroxiredoxin 6
  • Synonyms
    1-Cys, aiPLA2, AOP2, HEL-S-128m, LPCAT-5, NSGPx, p29, PRX
  • Links
    NCBI Gene ID: 9588
    UniProt: P30041

  • Chr Location
    1q25.1; chr1:173476814-173489064 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Male mice homozygous for a knock-out allele are fertile and exhibit normal testis gross appearance, normal testis and epididymis histology and germ cell number, and normal sperm morphology and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    24
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050114 Ensembl Gene Model | MGI Sequence Detail 2885 C57BL/6J ±  kb
transcript ENSMUST00000057072 Ensembl | MGI Sequence Detail 2885 Not Applicable  
polypeptide ENSMUSP00000133276 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 24
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1859817, MGI:2444701
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:51032 Phelan SA, et al., Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Genomics. 1998 Nov 15;54(1):132-9
  • Latest
    J:385753 Qiu Y, et al., CRISPR/Cas9-mediated Genome-editing Reveals 10 Testis-enriched Genes and One Non-testis-enriched Gene are Dispensable for Male Fecundity in Mice. Andrology. 2025 Nov 10;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory