Slc6a18 MGI Mouse Gene Detail - MGI:1336892 - solute carrier family 6 (neurotransmitter transporter), member 18

Symbol

Slc6a18
Name

solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms

D630001K16Rik, XT2, Xtrp2

Feature Type

protein coding gene
IDs

MGI:1336892
NCBI Gene: 22598
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:73809871-73826142 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.13 cM
Mapping Data

2 experiments

SNPs within 2kb

472 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336892	protein coding gene	Chr13:73809869-73826142 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020749	protein coding gene	Chr13:74129633-74149722 (-)
A/J	MGP_AJ_G0020705	protein coding gene	Chr13:71484409-71500638 (-)
AKR/J	MGP_AKRJ_G0020679	protein coding gene	Chr13:73731442-73747669 (-)
BALB/cJ	MGP_BALBcJ_G0020702	protein coding gene	Chr13:71975422-71992058 (-)
C3H/HeJ	MGP_C3HHeJ_G0020496	protein coding gene	Chr13:73411961-73429587 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021139	protein coding gene	Chr13:76600485-76617836 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018706	protein coding gene	Chr13:68303376-68320046 (-)
CAST/EiJ	MGP_CASTEiJ_G0020013	protein coding gene	Chr13:72491982-72509929 (-)
CBA/J	MGP_CBAJ_G0020455	protein coding gene	Chr13:79448287-79467731 (-)
DBA/2J	MGP_DBA2J_G0020580	protein coding gene	Chr13:71305186-71321441 (-)
FVB/NJ	MGP_FVBNJ_G0020560	protein coding gene	Chr13:70326384-70344341 (-)
LP/J	MGP_LPJ_G0020653	protein coding gene	Chr13:74372478-74389753 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020588	protein coding gene	Chr13:77878136-77895360 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021178	protein coding gene	Chr13:73040775-73057013 (-)
PWK/PhJ	MGP_PWKPhJ_G0019767	protein coding gene	Chr13:70039640-70056096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019590	protein coding gene	Chr13:69508238-69524458 (-)
WSB/EiJ	MGP_WSBEiJ_G0020071	protein coding gene	Chr13:73587667-73606510 (-)

Human Ortholog

SLC6A18, solute carrier family 6 member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC6A18, solute carrier family 6 member 18
Synonyms

Xtrp2
Links

HGNC:26441

NCBI Gene ID: 348932

neXtProt AC: NX_Q96N87

UniProt: Q96N87
Chr Location

5p15.33; chr5:1225381-1246189 (+) GRCh38

MGI Vertebrate Homology

Slc6a18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC6A18
Gene Tree

Slc6a18

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Slc6a18
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are overtly normal but have increased blood pressure associated with impaired renal accumulation of glycine.

less

All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

70
cDNA Data

60
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc6a18

less

All Sequences

70
RefSeq

12
UniProt

5
CCDS

CCDS36727.1, CCDS49311.1, CCDS49312.1, CCDS88479.1, CCDS88480.1, CCDS88481.1

Ensembl

ENSMUSG00000021612 (Evidence)
NCBI Gene

22598

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021612	Ensembl Gene Model \| MGI Sequence Detail	16272	C57BL/6J	± kb
transcript	ENSMUST00000222029	Ensembl \| MGI Sequence Detail	2005	Not Applicable
polypeptide	ENSMUSP00000152525	Ensembl \| MGI Sequence Detail	615	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000015184 inactive sodium-dependent neutral amino acid transporter B(0)AT3

(term hierarchy)
InterPro Domains

IPR042701 B0AT3, solute-binding domain

IPR002438 Neutral amino acid SLC6 transporter

IPR000175 Sodium:neurotransmitter symporter

IPR037272 Sodium:neurotransmitter symporter superfamily
GlyGen

O88576 3 sites

less

All nucleic 61

Genomic 1

cDNA 60

Microarray probesets 3

less

MGI:2444902

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 7
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:238554 Kaminski MM, et al., Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol. 2016 Dec;18(12):1269-1280

TSS for Slc6a18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123189	Chr13:73826274-73826299 (-)	-145 bp
Tssr123188	Chr13:73826148-73826159 (-)	-12 bp
Tssr123187	Chr13:73826124-73826145 (-)	7 bp
Tssr123186	Chr13:73826108-73826117 (-)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24