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Trp73 Gene Detail
Summary
  • Symbol
    Trp73
  • Name
    transformation related protein 73
  • Synonyms
    deltaNp73, p73, TAp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336991
    NCBI Gene: 22062
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154140706-154224332 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2410 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336991
 protein coding gene Chr4:154140706-154224665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029191
 protein coding gene Chr4:158300543-158365529 (-)
A/J MGP_AJ_G0029156
 protein coding gene Chr4:151658336-151719979 (-)
AKR/J MGP_AKRJ_G0029104
 protein coding gene Chr4:155794803-155858776 (-)
BALB/cJ MGP_BALBcJ_G0029172
 protein coding gene Chr4:152126403-152187077 (-)
C3H/HeJ MGP_C3HHeJ_G0028893
 protein coding gene Chr4:156327427-156392916 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029621
 protein coding gene Chr4:163959096-164054973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026867
 protein coding gene Chr4:143958111-144018464 (-)
CAST/EiJ MGP_CASTEiJ_G0028306
 protein coding gene Chr4:153725512-153788277 (-)
CBA/J MGP_CBAJ_G0028855
 protein coding gene Chr4:168882543-168950561 (-)
DBA/2J MGP_DBA2J_G0029004
 protein coding gene Chr4:151684890-151746785 (-)
FVB/NJ MGP_FVBNJ_G0028968
 protein coding gene Chr4:150885629-150950492 (-)
LP/J MGP_LPJ_G0029094
 protein coding gene Chr4:158208827-158274285 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028995
 protein coding gene Chr4:171804685-171868071 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029653
 protein coding gene Chr4:156360163-156425120 (-)
PWK/PhJ MGP_PWKPhJ_G0028026
 protein coding gene Chr4:147761073-147830387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027860
 protein coding gene Chr4:150650897-150741812 (-)
WSB/EiJ MGP_WSBEiJ_G0028386
 protein coding gene Chr4:156525570-156591150 (-)



Homology
more
  • Human Ortholog
    TP73, tumor protein p73
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP73, tumor protein p73
  • Synonyms
    CILD47, P73
  • Links
    NCBI Gene ID: 7161
    neXtProt AC: NX_O15350
    UniProt: O15350

  • Chr Location
    1p36.32; chr1:3652516-3736201 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trp73 mouse models; 12 with human TP73 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 5 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display a variety of defects including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, abnormal pheromone sensory pathways, eye abnormalities, impaired growth, and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    79
  • cDNA Data
    20
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22062 NCBI Gene Model | MGI Sequence Detail 83627 C57BL/6J ±  kb
    transcript NM_001126330 RefSeq | MGI Sequence Detail 4756 ZRU/MplStud  
    polypeptide Q9JJP2 UniProt | EBI | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000016568 tumor protein p73
      (term hierarchy)
    • InterPro Domains
      IPR011615 p53, DNA-binding domain
      IPR036674 p53-like tetramerisation domain superfamily
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
      IPR010991 p53, tetramerisation domain
      IPR002117 p53 tumour suppressor family
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR037612 Tumour protein p73, SAM domain
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 21
      Primer pair 10
      Other 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 211
      Developmental Gene Expression 63
      Diseases 1
      Gene Ontology 20
      Phenotypes 96
    • Earliest
      J:54538 Herranz M, et al., Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. Cancer Res. 1999 May 1;59(9):2068-71
    • Latest
      J:354217 Ohyama K, et al., Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors. Front Neurosci. 2024;18:1425849
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory