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Ankfy1 Gene Detail
Summary
  • Symbol
    Ankfy1
  • Name
    ankyrin repeat and FYVE domain containing 1
  • Synonyms
    Ankhzn, mKIAA1255
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337008
    NCBI Gene: 11736
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72580832-72662972 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 44.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1411 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337008
 protein coding gene Chr11:72580828-72662972 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018644
 protein coding gene Chr11:73341641-73423075 (+)
A/J MGP_AJ_G0018612
 protein coding gene Chr11:70591787-70673120 (+)
AKR/J MGP_AKRJ_G0018581
 protein coding gene Chr11:72741608-72825085 (+)
BALB/cJ MGP_BALBcJ_G0018584
 protein coding gene Chr11:70889952-70974297 (+)
C3H/HeJ MGP_C3HHeJ_G0018397
 protein coding gene Chr11:72702535-72785833 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019035
 protein coding gene Chr11:75554846-75645190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016678
 protein coding gene Chr11:67414821-67492573 (+)
CAST/EiJ MGP_CASTEiJ_G0017952
 protein coding gene Chr11:73076109-73163343 (+)
CBA/J MGP_CBAJ_G0018369
 protein coding gene Chr11:78922174-79016988 (+)
DBA/2J MGP_DBA2J_G0018478
 protein coding gene Chr11:70223304-70302833 (+)
FVB/NJ MGP_FVBNJ_G0018469
 protein coding gene Chr11:69766010-69846089 (+)
LP/J MGP_LPJ_G0018549
 protein coding gene Chr11:73842981-73924725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018492
 protein coding gene Chr11:79451186-79539773 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019077
 protein coding gene Chr11:72934272-73018092 (+)
PWK/PhJ MGP_PWKPhJ_G0017725
 protein coding gene Chr11:70850826-70933115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017515
 protein coding gene Chr11:72658918-72741721 (+)
WSB/EiJ MGP_WSBEiJ_G0018006
 protein coding gene Chr11:72681761-72762929 (+)



Homology
more
  • Human Ortholog
    ANKFY1, ankyrin repeat and FYVE domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKFY1, ankyrin repeat and FYVE domain containing 1
  • Synonyms
    ANKHZN, BTBD23, ZFYVE14
  • Links
    NCBI Gene ID: 51479
    neXtProt AC: NX_Q9P2R3
    UniProt: Q9P2R3

  • Chr Location
    17p13.2; chr17:4163821-4263995 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ankfy1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial embryonic lethality with no apparent neural developmental defects on a mixed genetic background but show complete embryonic lethality on highly homogenous genetic backgrounds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    146
  • cDNA Data
    186
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020790 Ensembl Gene Model | MGI Sequence Detail 82141 C57BL/6J ±  kb
    transcript ENSMUST00000155998 Ensembl | MGI Sequence Detail 8030 Not Applicable  
    polypeptide ENSMUSP00000118751 Ensembl | MGI Sequence Detail 1169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 191
      cDNA 187
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory