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Serf2 Gene Detail
Summary
  • Symbol
    Serf2
  • Name
    small EDRK-rich factor 2
  • Synonyms
    4F5rel (4F5 related), m4F5rel
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337041
    NCBI Gene: 378702
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121279679-121283901 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.39 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337041
 protein coding gene Chr2:121279676-121288794 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026394
 protein coding gene Chr2:124352151-124361228 (+)
A/J MGP_AJ_G0026355
 protein coding gene Chr2:119267270-119276440 (+)
AKR/J MGP_AKRJ_G0026334
 protein coding gene Chr2:122613282-122622290 (+)
BALB/cJ MGP_BALBcJ_G0026368
 protein coding gene Chr2:119497443-119506507 (+)
C3H/HeJ MGP_C3HHeJ_G0026114
 protein coding gene Chr2:123093676-123102692 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026815
 protein coding gene Chr2:128421280-128432282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024195
 protein coding gene Chr2:114308046-114317230 (+)
CAST/EiJ MGP_CASTEiJ_G0025576
 protein coding gene Chr2:123421906-123431068 (+)
CBA/J MGP_CBAJ_G0026090
 protein coding gene Chr2:132890952-132903408 (+)
DBA/2J MGP_DBA2J_G0026229
 protein coding gene Chr2:118665835-118690357 (+)
FVB/NJ MGP_FVBNJ_G0026191
 protein coding gene Chr2:117485557-117494623 (+)
LP/J MGP_LPJ_G0026330
 protein coding gene Chr2:124599886-124609443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026210
 protein coding gene Chr2:137170326-137181952 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026870
 protein coding gene Chr2:122723847-122732931 (+)
PWK/PhJ MGP_PWKPhJ_G0025312
 protein coding gene Chr2:118272679-118282032 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025111
 protein coding gene Chr2:121931270-121940445 (+)
WSB/EiJ MGP_WSBEiJ_G0025645
 protein coding gene Chr2:123561255-123571660 (+)



Homology
more
  • Human Ortholog
    SERF2, small EDRK-rich factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERF2, small EDRK-rich factor 2
  • Synonyms
    4F5REL, FAM2C, H4F5REL, Hero7, HsT17089
  • Links
    NCBI Gene ID: 10169
    neXtProt AC: NX_P84101
    UniProt: P84101

  • Chr Location
    15q15.3; chr15:43777086-43804427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    30
  • cDNA Data
    372
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 378702 NCBI Gene Model | MGI Sequence Detail 4223 C57BL/6J ±  kb
transcript NR_110986 RefSeq | MGI Sequence Detail 3205 C57BL/6  
polypeptide P84102 UniProt | EBI | MGI Sequence Detail 59 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 374
    Genomic 1
    cDNA 372
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1313321, MGI:2139496
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:335458 Stroo E, et al., Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Life Sci Alliance. 2023 Jul;6(7):e202201730
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory