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Ap3s2 Gene Detail
Summary
  • Symbol
    Ap3s2
  • Name
    adaptor-related protein complex 3, sigma 2 subunit
  • Synonyms
    [s]3B, sigma 3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337060
    NCBI Gene: 11778
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79525073-79570388 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.23 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1234 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337060
 protein coding gene Chr7:79525073-79570397 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032399
 protein coding gene Chr7:81789861-81837811 (-)
A/J MGP_AJ_G0032378
 protein coding gene Chr7:79903401-79948991 (-)
AKR/J MGP_AKRJ_G0032314
 protein coding gene Chr7:81620956-81665947 (-)
BALB/cJ MGP_BALBcJ_G0032390
 protein coding gene Chr7:79584947-79631727 (-)
C3H/HeJ MGP_C3HHeJ_G0032103
 protein coding gene Chr7:82271525-82319126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032882
 protein coding gene Chr7:85001168-85046518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029890
 protein coding gene Chr7:82428777-82474751 (-)
CAST/EiJ MGP_CASTEiJ_G0031431
 protein coding gene Chr7:73146019-73190533 (-)
CBA/J MGP_CBAJ_G0032069
 protein coding gene Chr7:87838507-87887046 (-)
DBA/2J MGP_DBA2J_G0032224
 protein coding gene Chr7:78459137-78505484 (-)
FVB/NJ MGP_FVBNJ_G0032179
 protein coding gene Chr7:78373208-78417994 (-)
LP/J MGP_LPJ_G0032305
 protein coding gene Chr7:83041556-83091981 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032216
 protein coding gene Chr7:88002083-88048908 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032900
 protein coding gene Chr7:81059253-81106900 (-)
PWK/PhJ MGP_PWKPhJ_G0031151
 protein coding gene Chr7:71642596-71685032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030992
 protein coding gene Chr7:68062311-68109646 (-)
WSB/EiJ MGP_WSBEiJ_G0031549
 protein coding gene Chr7:81382044-81428273 (-)



Homology
more
  • Human Ortholog
    AP3S2, adaptor related protein complex 3 subunit sigma 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP3S2, adaptor related protein complex 3 subunit sigma 2
  • Synonyms
    AP3S3, sigma3b
  • Links
    NCBI Gene ID: 10239
    neXtProt AC: NX_P59780
    UniProt: P59780

  • Chr Location
    15q26.1; chr15:89830599-89894638 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    43
  • cDNA Data
    121
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11778 NCBI Gene Model | MGI Sequence Detail 45316 C57BL/6J ±  kb
    transcript NM_009682 RefSeq | MGI Sequence Detail 5823 C57BL/6  
    polypeptide Q8BSZ2 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 1
      cDNA 121

      Microarray probesets 10
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory