Serf1 MGI Mouse Gene Detail - MGI:1337114

Symbol

Serf1
Name

small EDRK-rich factor 1
Synonyms

4F5, m4F5

Feature Type

protein coding gene
IDs

MGI:1337114
NCBI Gene: 20365
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:100244563-100250741 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 52.98 cM
Mapping Data

9 experiments

SNPs within 2kb

8 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337114	protein coding gene	Chr13:100244520-100251079 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020880	protein coding gene	Chr13:101940643-101952625 (+)
A/J	MGP_AJ_G0020834	protein coding gene	Chr13:98017513-98030023 (+)
AKR/J	MGP_AKRJ_G0020808	protein coding gene	Chr13:101012455-101018949 (+)
BALB/cJ	MGP_BALBcJ_G0020832	protein coding gene	Chr13:98724619-98731425 (+)
C3H/HeJ	MGP_C3HHeJ_G0020623	protein coding gene	Chr13:100731897-100739232 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021266	protein coding gene	Chr13:104970598-104976933 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018835	protein coding gene	Chr13:93730970-93737782 (+)
CAST/EiJ	MGP_CASTEiJ_G0020141	protein coding gene	Chr13:100175596-100184556 (+)
CBA/J	MGP_CBAJ_G0020583	protein coding gene	Chr13:109143218-109149521 (+)
DBA/2J	MGP_DBA2J_G0020708	protein coding gene	Chr13:97780269-97786639 (+)
FVB/NJ	MGP_FVBNJ_G0020689	protein coding gene	Chr13:96525619-96532071 (+)
LP/J	MGP_LPJ_G0020783	protein coding gene	Chr13:102023132-102029497 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020717	protein coding gene	Chr13:109391234-109397727 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021307	protein coding gene	Chr13:100471637-100485096 (+)
PWK/PhJ	MGP_PWKPhJ_G0019894	protein coding gene	Chr13:96611972-96618527 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019717	protein coding gene	Chr13:96751690-96762612 (+)
WSB/EiJ	MGP_WSBEiJ_G0020199	protein coding gene	Chr13:100896698-100903571 (+)

Human Ortholog

SERF1A, small EDRK-rich factor 1A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERF1A, small EDRK-rich factor 1A
Synonyms

4F5, FAM2A, H4F5, SERF1, SMAM1
Links

HGNC:10755

NCBI Gene ID: 8293

neXtProt AC: NX_O75920

UniProt: O75920
Chr Location

5q13.2

Human Ortholog

SERF1B, small EDRK-rich factor 1B
Synonyms

FAM2B, h4F5, H4F5C
Links

HGNC:10756

NCBI Gene ID: 728492

neXtProt AC: NX_O75920

UniProt: O75920
Chr Location

5q13.2; chr5:70025251-70043113 (+) GRCh38

MGI Vertebrate Homology

Serf1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SERF1A, SERF1B
Gene Tree

Serf1

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Targeted

3
Transgenic

1
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

8
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

28
cDNA Data

78
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

less

All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS36765.1

Ensembl

ENSMUSG00000021643 (Evidence)
NCBI Gene

20365

			Length	Strain/Species	Flank
genomic	20365	NCBI Gene Model \| MGI Sequence Detail	6179	C57BL/6J	± kb
transcript	NM_011353	RefSeq \| MGI Sequence Detail	553	ZRU/MplStud
polypeptide	O88892	UniProt \| EBI \| MGI Sequence Detail	62	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000015926 small EDRK-rich factor 1

(term hierarchy)
InterPro Domains

IPR040211 Small EDRK-rich factor 1/2-like

IPR007513 Small EDRK-rich factor-like, N-terminal

less

All nucleic 95

Genomic 15

cDNA 79

Primer pair 1

Microarray probesets 6

less

MGI:1313296

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 7
Earliest

J:49474 Kim PS, et al., A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9909-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Serf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120840	Chr13:100244515-100244520 (+)	-45 bp
Tssr120841	Chr13:100244522-100244651 (+)	24 bp
Tssr120842	Chr13:100244664-100244675 (+)	107 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24