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Zdhhc8 Gene Detail
Summary
  • Symbol
    Zdhhc8
  • Name
    zinc finger, DHHC domain containing 8
  • Synonyms
    D16H22S1738E, E330009O14Rik, MGC:7847, Op53c05
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338012
    NCBI Gene: 27801
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18038617-18053000 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.29 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338012
 protein coding gene Chr16:18038612-18056471 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022604
 protein coding gene Chr16:15428024-15442400 (-)
A/J MGP_AJ_G0022565
 protein coding gene Chr16:14664550-14678976 (-)
AKR/J MGP_AKRJ_G0022542
 protein coding gene Chr16:15241642-15255428 (-)
BALB/cJ MGP_BALBcJ_G0022570
 protein coding gene Chr16:14813429-14828345 (-)
C3H/HeJ MGP_C3HHeJ_G0022337
 protein coding gene Chr16:15404870-15420677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023019
 protein coding gene Chr16:15694883-15710963 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020539
 protein coding gene Chr16:14715381-14729814 (-)
CAST/EiJ MGP_CASTEiJ_G0021864
 protein coding gene Chr16:15293203-15307877 (-)
CBA/J MGP_CBAJ_G0022306
 protein coding gene Chr16:16381329-16398504 (-)
DBA/2J MGP_DBA2J_G0022438
 protein coding gene Chr16:14575728-14590115 (-)
FVB/NJ MGP_FVBNJ_G0022413
 protein coding gene Chr16:14633107-14647572 (-)
LP/J MGP_LPJ_G0022505
 protein coding gene Chr16:15211783-15226264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022435
 protein coding gene Chr16:16034396-16050094 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023030
 protein coding gene Chr16:15176452-15192862 (-)
PWK/PhJ MGP_PWKPhJ_G0021606
 protein coding gene Chr16:14845955-14860835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021434
 protein coding gene Chr16:15147583-15161363 (-)
WSB/EiJ MGP_WSBEiJ_G0021910
 protein coding gene Chr16:15162952-15177307 (-)



Homology
more
  • Human Ortholog
    ZDHHC8, zinc finger DHHC-type palmitoyltransferase 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC8, zinc finger DHHC-type palmitoyltransferase 8
  • Synonyms
    DHHC8, ZDHHCL1, ZNF378
  • Links
    NCBI Gene ID: 29801
    neXtProt AC: NX_Q9ULC8
    UniProt: Q9ULC8

  • Chr Location
    22q11.21; chr22:20129456-20148007 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females display impaired prepulse inhibition and reduced exploration in new environments. Homozygous null males display normal prepulse inhibition and only a slight decrease in exploration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    38
  • cDNA Data
    48
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060166 Ensembl Gene Model | MGI Sequence Detail 14384 C57BL/6J ±  kb
transcript ENSMUST00000076957 Ensembl | MGI Sequence Detail 4868 Not Applicable  
polypeptide ENSMUSP00000076224 Ensembl | MGI Sequence Detail 762 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    Genomic 7
    cDNA 48
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1927905, MGI:2442027
References
more
  • Summaries
    All 171
    Developmental Gene Expression 6
    Diseases 6
    Gene Ontology 12
    Phenotypes 135
  • Earliest
    J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
  • Latest
    J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory