Klf5 MGI Mouse Gene Detail - MGI:1338056 - Kruppel-like transcription factor 5

Symbol

Klf5
Name

Kruppel-like transcription factor 5
Synonyms

4930520J07Rik, Bteb2, CKLF, IKLF

Feature Type

protein coding gene
IDs

MGI:1338056
NCBI Gene: 12224
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:99536127-99550848 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 49.43 cM, cytoband E2.1
Mapping Data

3 experiments

SNPs within 2kb

359 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338056	protein coding gene	Chr14:99536127-99552472 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021618	protein coding gene	Chr14:95584874-95599588 (+)
A/J	MGP_AJ_G0021576	protein coding gene	Chr14:92536274-92550988 (+)
AKR/J	MGP_AKRJ_G0021552	protein coding gene	Chr14:95258556-95273308 (+)
BALB/cJ	MGP_BALBcJ_G0021582	protein coding gene	Chr14:92871792-92886506 (+)
C3H/HeJ	MGP_C3HHeJ_G0021360	protein coding gene	Chr14:95142651-95157365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022022	protein coding gene	Chr14:99490678-99505392 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019562	protein coding gene	Chr14:89586862-89601787 (+)
CAST/EiJ	MGP_CASTEiJ_G0020877	protein coding gene	Chr14:92439642-92456125 (+)
CBA/J	MGP_CBAJ_G0021328	protein coding gene	Chr14:103168710-103183461 (+)
DBA/2J	MGP_DBA2J_G0021452	protein coding gene	Chr14:92030154-92044889 (+)
FVB/NJ	MGP_FVBNJ_G0021429	protein coding gene	Chr14:91069351-91084065 (+)
LP/J	MGP_LPJ_G0021520	protein coding gene	Chr14:96384540-96399254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021456	protein coding gene	Chr14:105889241-105903955 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022045	protein coding gene	Chr14:94769713-94784427 (+)
PWK/PhJ	MGP_PWKPhJ_G0020620	protein coding gene	Chr14:89018160-89033003 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020458	protein coding gene	Chr14:90750328-90764972 (+)
WSB/EiJ	MGP_WSBEiJ_G0020930	protein coding gene	Chr14:95373175-95387915 (+)

Human Ortholog

KLF5, KLF transcription factor 5

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLF5, KLF transcription factor 5
Synonyms

BTEB2, CKLF, IKLF
Links

HGNC:6349

NCBI Gene ID: 688

neXtProt AC: NX_Q13887

UniProt: Q13887
Chr Location

13q22.1; chr13:73054976-73077541 (+) GRCh38

MGI Vertebrate Homology

Klf5 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: KLF5
Gene Tree

Klf5

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Phenotype Summary

98 phenotypes from 8 alleles in 12 genetic backgrounds
6 phenotypes from multigenic genotypes
6 images
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

26
Targeted

12
Genomic Mutations

1 involving Klf5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die during gestation, while heterozygotes exhibit abnormal cardiovascular remodeling after external stress. Mice homozygous for a floxed allele activated in the prostate exhibit increased cell proliferation and hyperplasia in the prostate without neoplasia.

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All GO Annotations

59
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

997
Tissues

138
cDNA Data

24
Literature Summary

48

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KLF5

Xenbase klf5

ZFIN klf5a, klf5b

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All Sequences

48
RefSeq

2
UniProt

2
CCDS

CCDS27311.1

Ensembl

ENSMUSG00000005148 (Evidence)
NCBI Gene

12224

			Length	Strain/Species	Flank
genomic	12224	NCBI Gene Model \| MGI Sequence Detail	14722	C57BL/6J	± kb
transcript	NM_009769	RefSeq \| MGI Sequence Detail	1728	C57BL/6
polypeptide	Q9Z0Z7	UniProt \| EBI \| MGI Sequence Detail	446	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009365 krueppel-like factor 5

(term hierarchy)
InterPro Domains

IPR026205 Progesterone-induced-blocking factor 1

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q9Z0Z7 1 site, 1 O-linked glycan (1 site)

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All nucleic 34

cDNA 25

Primer pair 7

Other 2

Microarray probesets 5

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MGI:1922343

Summaries

All 157

Developmental Gene Expression 48

Gene Ontology 14

Phenotypes 61
Earliest

J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
Latest

J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166

TSS for Klf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126881	Chr14:99536088-99536151 (+)	-7 bp
Tssr126882	Chr14:99536381-99536425 (+)	276 bp
Tssr126883	Chr14:99539070-99539098 (+)	2,957 bp
Tssr126884	Chr14:99539099-99539122 (+)	2,984 bp
Tssr126885	Chr14:99539124-99539139 (+)	3,005 bp
Tssr126886	Chr14:99539239-99539250 (+)	3,118 bp
Tssr126887	Chr14:99539335-99539349 (+)	3,215 bp
Tssr126888	Chr14:99539417-99539464 (+)	3,314 bp
Tssr126889	Chr14:99548382-99548385 (+)	12,257 bp
Tssr126890	Chr14:99550765-99550811 (+)	14,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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