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Defb2 Gene Detail
Summary
  • Symbol
    Defb2
  • Name
    defensin beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338754
    NCBI Gene: 13215
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22329942-22333498 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.45 cM, cytoband A4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338754
 protein coding gene Chr8:22329942-22333519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033433
 protein coding gene Chr8:19615215-19619261 (+)
A/J MGP_AJ_G0033413
 protein coding gene Chr8:19024878-19028464 (+)
AKR/J MGP_AKRJ_G0033340
 protein coding gene Chr8:19656895-19657370 (+)
BALB/cJ MGP_BALBcJ_G0033409
 protein coding gene Chr8:19153165-19156745 (+)
C3H/HeJ MGP_C3HHeJ_G0033123
 protein coding gene Chr8:19816841-19817316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033926
 protein coding gene Chr8:20477829-20478304 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032449
 protein coding gene Chr8:19252354-19252829 (+)
CBA/J MGP_CBAJ_G0033098
 protein coding gene Chr8:21311739-21312214 (+)
DBA/2J MGP_DBA2J_G0033253
 protein coding gene Chr8:18994951-18995426 (+)
FVB/NJ MGP_FVBNJ_G0033197
 protein coding gene Chr8:18769390-18772805 (+)
LP/J MGP_LPJ_G0033342
 protein coding gene Chr8:19643351-19646955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033240
 protein coding gene Chr8:20928856-20934861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033945
 protein coding gene Chr8:19551510-19556548 (+)
PWK/PhJ MGP_PWKPhJ_G0032161
 protein coding gene Chr8:18598739-18599214 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032566
 protein coding gene Chr8:19690447-19696241 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006570 Ensembl Gene Model | MGI Sequence Detail 3557 C57BL/6J ±  kb
transcript ENSMUST00000006745 Ensembl | MGI Sequence Detail 305 Not Applicable  
polypeptide ENSMUSP00000006745 Ensembl | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:52008 Morrison GM, et al., A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide. FEBS Lett. 1999 Jan 8;442(1):112-6
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory