Trim10 MGI Mouse Gene Detail - MGI:1338757 - tripartite motif-containing 10

Symbol

Trim10
Name

tripartite motif-containing 10
Synonyms

Herf1, Rnf9

Feature Type

protein coding gene
IDs

MGI:1338757
NCBI Gene: 19824
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:37180466-37188725 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.16 cM
Mapping Data

2 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338757	protein coding gene	Chr17:37180388-37188725 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023684	protein coding gene	Chr17:37219310-37228762 (+)
A/J	MGP_AJ_G0023642	protein coding gene	Chr17:36049345-36057617 (+)
AKR/J	MGP_AKRJ_G0023613	protein coding gene	Chr17:36483438-36491677 (+)
BALB/cJ	MGP_BALBcJ_G0023649	protein coding gene	Chr17:36289987-36298242 (+)
C3H/HeJ	MGP_C3HHeJ_G0023411	protein coding gene	Chr17:36997224-37005463 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024087	protein coding gene	Chr17:38818271-38826512 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021555	protein coding gene	Chr17:33861955-33872526 (+)
CAST/EiJ	MGP_CASTEiJ_G0022896	protein coding gene	Chr17:37125435-37133680 (+)
CBA/J	MGP_CBAJ_G0023388	protein coding gene	Chr17:40333321-40341560 (+)
DBA/2J	MGP_DBA2J_G0023513	protein coding gene	Chr17:35441278-35449525 (+)
FVB/NJ	MGP_FVBNJ_G0023486	protein coding gene	Chr17:35050556-35058800 (+)
LP/J	MGP_LPJ_G0023591	protein coding gene	Chr17:37752899-37761141 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023509	protein coding gene	Chr17:39129434-39138584 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024132	protein coding gene	Chr17:36821316-36830633 (+)
PWK/PhJ	MGP_PWKPhJ_G0022648	protein coding gene	Chr17:34218468-34226701 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022467	protein coding gene	Chr17:34903276-34912800 (+)
WSB/EiJ	MGP_WSBEiJ_G0022963	protein coding gene	Chr17:37136580-37144849 (+)

Human Ortholog

TRIM10, tripartite motif containing 10

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM10, tripartite motif containing 10
Synonyms

HERF1, RFB30, RNF9
Links

HGNC:10072

NCBI Gene ID: 10107

neXtProt AC: NX_Q9UDY6

UniProt: Q9UDY6
Chr Location

6p22.1; chr6:30151943-30164009 (-) GRCh38

MGI Vertebrate Homology

Trim10 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: TRIM10
Gene Tree

Trim10

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Genomic Mutations

1 involving Trim10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show prevention of transverse aortic constriction-induced cardiac hypertrophy.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

67
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

8
UniProt

1
CCDS

CCDS37614.1

Ensembl

ENSMUSG00000073400 (Evidence)
NCBI Gene

19824

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073400	Ensembl Gene Model \| MGI Sequence Detail	8260	C57BL/6J	± kb
transcript	ENSMUST00000060524	Ensembl \| MGI Sequence Detail	2245	Not Applicable
polypeptide	ENSMUSP00000057928	Ensembl \| MGI Sequence Detail	489	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016641 tripartite motif-containing protein 10

(term hierarchy)
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR000315 B-box-type zinc finger

IPR003879 Butyrophylin-like, SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR006574 SPRY-associated

IPR003877 SPRY domain

IPR050143 Tripartite motif-containing

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:2146826, MGI:2147109

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 6
Earliest

J:54633 Harada H, et al., HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Mol Cell Biol. 1999 May;19(5):3808-15
Latest

J:348568 Kong L, et al., The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023 Mar 26;42(4):112306

TSS for Trim10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144512	Chr17:37180405-37180421 (+)	-53 bp
Tssr144513	Chr17:37180424-37180433 (+)	-37 bp
Tssr144514	Chr17:37180438-37180457 (+)	-18 bp
Tssr144515	Chr17:37180459-37180473 (+)	0 bp
Tssr144516	Chr17:37180994-37181034 (+)	548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24