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Adnp Gene Detail
Summary
  • Symbol
    Adnp
  • Name
    activity-dependent neuroprotective protein
  • Synonyms
    mKIAA0784
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338758
    NCBI Gene: 11538
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:168022906-168049032 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 88.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338758
 protein coding gene Chr2:168022885-168049032 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026922
 protein coding gene Chr2:174010535-174037074 (-)
A/J MGP_AJ_G0026889
 protein coding gene Chr2:166814319-166840384 (-)
AKR/J MGP_AKRJ_G0026860
 protein coding gene Chr2:171792439-171818475 (-)
BALB/cJ MGP_BALBcJ_G0026898
 protein coding gene Chr2:167169570-167195629 (-)
C3H/HeJ MGP_C3HHeJ_G0026640
 protein coding gene Chr2:172162432-172188502 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027345
 protein coding gene Chr2:179087823-179115829 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024716
 protein coding gene Chr2:160119068-160144337 (-)
CAST/EiJ MGP_CASTEiJ_G0026098
 protein coding gene Chr2:172640249-172666302 (-)
CBA/J MGP_CBAJ_G0026617
 protein coding gene Chr2:185671792-185697886 (-)
DBA/2J MGP_DBA2J_G0026755
 protein coding gene Chr2:165914115-165940440 (-)
FVB/NJ MGP_FVBNJ_G0026721
 protein coding gene Chr2:164480078-164506078 (-)
LP/J MGP_LPJ_G0026856
 protein coding gene Chr2:174015083-174042445 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026740
 protein coding gene Chr2:188981147-189007892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027403
 protein coding gene Chr2:171729558-171756592 (-)
PWK/PhJ MGP_PWKPhJ_G0025835
 protein coding gene Chr2:165604696-165631206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025636
 protein coding gene Chr2:170686735-170716025 (-)
WSB/EiJ MGP_WSBEiJ_G0026171
 protein coding gene Chr2:172634766-172660861 (-)



Homology
more
  • Human Ortholog
    ADNP, activity dependent neuroprotector homeobox
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADNP, activity dependent neuroprotector homeobox
  • Synonyms
    ADNP1, HVDAS, MRD28
  • Links
    NCBI Gene ID: 23394
    neXtProt AC: NX_Q9H2P0
    UniProt: Q9H2P0

  • Chr Location
    20q13.13; chr20:50888916-50931437 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADNP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Developmental defects including the failure of the cranial neural tube to close lead to embryonic death between E8.5 and E9.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    162
  • cDNA Data
    20
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051149 Ensembl Gene Model | MGI Sequence Detail 26127 C57BL/6J ±  kb
    transcript ENSMUST00000057793 Ensembl | MGI Sequence Detail 4917 Not Applicable  
    polypeptide ENSMUSP00000056809 Ensembl | MGI Sequence Detail 1108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003784 activity-dependent neuroprotector homeobox protein
      (term hierarchy)
    • InterPro Domains
      IPR038861 Activity-dependent neuroprotector homeobox protein
      IPR045762 ADNP, zinc finger domain
      IPR001356 Homeobox domain
      IPR009057 Homeobox-like domain superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      Q9Z103 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138798
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:1560 Pailhoux E, et al., The genomic organization and DNA sequence of the mouse vas deferens androgen-regulated protein gene. J Steroid Biochem Mol Biol. 1992 Jul;42(6):561-8
    • Latest
      J:355243 Clemot-Dupont S, et al., The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers. bioRxiv. 2024;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory