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Bmp10 Gene Detail
Summary
  • Symbol
    Bmp10
  • Name
    bone morphogenetic protein 10
  • Synonyms
    b2b2711Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338820
    NCBI Gene: 12154
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87405976-87411494 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.96 cM, cytoband D2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338820
 protein coding gene Chr6:87405976-87414659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030992
 protein coding gene Chr6:88774379-88783102 (+)
A/J MGP_AJ_G0030958
 protein coding gene Chr6:85342400-85351815 (+)
AKR/J MGP_AKRJ_G0030889
 protein coding gene Chr6:87813234-87821927 (+)
BALB/cJ MGP_BALBcJ_G0030971
 protein coding gene Chr6:85345337-85354572 (+)
C3H/HeJ MGP_C3HHeJ_G0030739
 protein coding gene Chr6:96656785-96666282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031428
 protein coding gene Chr6:91161960-91171529 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028612
 protein coding gene Chr6:83525708-83535416 (+)
CAST/EiJ MGP_CASTEiJ_G0030080
 protein coding gene Chr6:87885111-87893428 (+)
CBA/J MGP_CBAJ_G0030655
 protein coding gene Chr6:94699286-94708723 (+)
DBA/2J MGP_DBA2J_G0030811
 protein coding gene Chr6:84648854-84657741 (+)
FVB/NJ MGP_FVBNJ_G0030764
 protein coding gene Chr6:83829046-83840115 (+)
LP/J MGP_LPJ_G0030888
 protein coding gene Chr6:88786326-88796196 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030797
 protein coding gene Chr6:98818942-98828767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031455
 protein coding gene Chr6:87654912-87665786 (+)
PWK/PhJ MGP_PWKPhJ_G0029795
 protein coding gene Chr6:83612076-83620777 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029623
 protein coding gene Chr6:86475440-86484130 (+)
WSB/EiJ MGP_WSBEiJ_G0030161
 protein coding gene Chr6:88115503-88125422 (+)



Homology
more
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP10, bone morphogenetic protein 10
  • Links
    NCBI Gene ID: 27302
    neXtProt AC: NX_O95393
    UniProt: O95393

  • Chr Location
    2p13.3; chr2:68860909-68871397 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bmp10 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    13 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased embryo size, cardiac dysgenesis, defects in early embryonic vascular development, enlarged pericardium, arteriovenous malformations, and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    58
  • cDNA Data
    4
  • Literature Summary
    102
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12154 NCBI Gene Model | MGI Sequence Detail 5519 C57BL/6J ±  kb
    transcript NM_009756 RefSeq | MGI Sequence Detail 1325 C57BL/6  
    polypeptide Q9R229 UniProt | EBI | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 4
      Primer pair 8
      Other 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5616115
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 102
      Diseases 1
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:53506 Neuhaus H, et al., Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb;80(2):181-4
    • Latest
      J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory