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Celf2 Gene Detail
Summary
  • Symbol
    Celf2
  • Name
    CUGBP, Elav-like family member 2
  • Synonyms
    B230345P09Rik, Cugbp2, ETR-3, Napor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338822
    NCBI Gene: 14007
  • Alliance
    gene page
  • Transcription Start Sites
    81 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:6544505-7401345 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.69 cM, cytoband A2-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338822
 protein coding gene Chr2:6544505-7514374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025332
 protein coding gene Chr2:3719904-4714863 (-)
A/J MGP_AJ_G0025309
 protein coding gene Chr2:3533016-4490623 (-)
AKR/J MGP_AKRJ_G0025277
 protein coding gene Chr2:3653412-4664182 (-)
BALB/cJ MGP_BALBcJ_G0025305
 protein coding gene Chr2:3521769-4485158 (-)
C3H/HeJ MGP_C3HHeJ_G0025065
 protein coding gene Chr2:3586944-4583132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025747
 protein coding gene Chr2:3819230-4852467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023161
 protein coding gene Chr2:3324191-4157654 (-)
CAST/EiJ MGP_CASTEiJ_G0024528
 protein coding gene Chr2:3662152-4656697 (-)
CBA/J MGP_CBAJ_G0025044
 protein coding gene Chr2:3993932-5062300 (-)
DBA/2J MGP_DBA2J_G0025176
 protein coding gene Chr2:3482093-4461185 (-)
FVB/NJ MGP_FVBNJ_G0025138
 protein coding gene Chr2:3483074-4440512 (-)
LP/J MGP_LPJ_G0025262
 protein coding gene Chr2:3652199-4630306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025170
 protein coding gene Chr2:3786656-4817275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025805
 protein coding gene Chr2:3640227-4619354 (-)
PWK/PhJ MGP_PWKPhJ_G0024279
 protein coding gene Chr2:3481565-4436459 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024079
 protein coding gene Chr2:3639263-4600733 (-)
WSB/EiJ MGP_WSBEiJ_G0024598
 protein coding gene Chr2:3684876-4677757 (-)



Homology
more
  • Human Ortholog
    CELF2, CUGBP Elav-like family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELF2, CUGBP Elav-like family member 2
  • Synonyms
    BRUNOL3, CELF-2, CUG-BP2, CUGBP2, DEE97, ETR-3, ETR3, NAPOR
  • Links
    NCBI Gene ID: 10659
    neXtProt AC: NX_O95319
    UniProt: O95319

  • Chr Location
    10p14; chr10:10462550-11336675 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CELF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die neonatally and postnatally with reduced axon extension in DRG explants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    97
  • cDNA Data
    37
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14007 NCBI Gene Model | MGI Sequence Detail 856841 C57BL/6J ±  kb
    transcript NM_001406943 RefSeq | MGI Sequence Detail 15747 C57BL/6  
    polypeptide Q9Z0H4 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 39
      Primer pair 5
      Other 2

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGI:2139536, MGI:2442223
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:52367 Lu X, et al., Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. Hum Mol Genet. 1999 Jan;8(1):53-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory