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Maz Gene Detail
Summary
  • Symbol
    Maz
  • Name
    MYC-associated zinc finger protein (purine-binding transcription factor)
  • Synonyms
    Pur-1, PUR1, SAF-1, SAF-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338823
    NCBI Gene: 17188
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126621306-126626177 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.28 cM, cytoband F4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338823
 protein coding gene Chr7:126621302-126626209 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033017
 protein coding gene Chr7:131336317-131340764 (-)
A/J MGP_AJ_G0033000
 protein coding gene Chr7:127849722-127854171 (-)
AKR/J MGP_AKRJ_G0032932
 protein coding gene Chr7:131085405-131089851 (-)
BALB/cJ MGP_BALBcJ_G0033005
 protein coding gene Chr7:127513144-127517590 (-)
C3H/HeJ MGP_C3HHeJ_G0032715
 protein coding gene Chr7:131027869-131032316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033511
 protein coding gene Chr7:136440633-136446638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030483
 protein coding gene Chr7:129062206-129066664 (-)
CAST/EiJ MGP_CASTEiJ_G0032044
 protein coding gene Chr7:122817431-122821867 (-)
CBA/J MGP_CBAJ_G0032688
 protein coding gene Chr7:141028543-141032990 (-)
DBA/2J MGP_DBA2J_G0032840
 protein coding gene Chr7:125823776-125828223 (-)
FVB/NJ MGP_FVBNJ_G0032793
 protein coding gene Chr7:125675101-125679548 (-)
LP/J MGP_LPJ_G0032934
 protein coding gene Chr7:132806892-132811339 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032825
 protein coding gene Chr7:142194441-142198883 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033530
 protein coding gene Chr7:130102024-130106470 (-)
PWK/PhJ MGP_PWKPhJ_G0031751
 protein coding gene Chr7:118820419-118824866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031597
 protein coding gene Chr7:116942804-116947232 (-)
WSB/EiJ MGP_WSBEiJ_G0032156
 protein coding gene Chr7:131077658-131082106 (-)



Homology
more
  • Human Ortholog
    MAZ, MYC associated zinc finger protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAZ, MYC associated zinc finger protein
  • Synonyms
    Pur-1, PUR1, SAF-1, SAF-2, SAF-3, ZF87, Zif87, ZNF801
  • Links
    NCBI Gene ID: 4150
    neXtProt AC: NX_P56270
    UniProt: P56270

  • Chr Location
    16p11.2; chr16:29806106-29811164 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit fetal and postnatal lethality, kidney agenesis, and impacts fertility in rare surviving mice. Mice heterozygous for this allele exhibit fetal lethality and abnormal bladder function and architecture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    147
  • cDNA Data
    176
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17188 NCBI Gene Model | MGI Sequence Detail 4872 C57BL/6J ±  kb
    transcript NM_001372522 RefSeq | MGI Sequence Detail 2715 C57BL/6  
    polypeptide P56671 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 1
      cDNA 177
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 11
      Phenotypes 50
    • Earliest
      J:54443 Kennedy GC, et al., Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11498-502
    • Latest
      J:359305 Choi A, et al., Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience. 2024 Dec 20;27(12):111285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory