Rgs9 MGI Mouse Gene Detail - MGI:1338824 - regulator of G-protein signaling 9

Symbol

Rgs9
Name

regulator of G-protein signaling 9
Synonyms

RGS9-1, Rgs9-2

Feature Type

protein coding gene
IDs

MGI:1338824
NCBI Gene: 19739
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:109116181-109188955 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 71.86 cM
Mapping Data

4 experiments

SNPs within 2kb

2567 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338824	protein coding gene	Chr11:109116174-109189013 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019330	protein coding gene	Chr11:112759257-112838964 (-)
A/J	MGP_AJ_G0019298	protein coding gene	Chr11:107889377-107962448 (-)
AKR/J	MGP_AKRJ_G0019267	protein coding gene	Chr11:111118054-111194271 (-)
BALB/cJ	MGP_BALBcJ_G0019272	protein coding gene	Chr11:108322822-108395870 (-)
C3H/HeJ	MGP_C3HHeJ_G0019081	protein coding gene	Chr11:111426039-111504752 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019722	protein coding gene	Chr11:116176362-116259279 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017346	protein coding gene	Chr11:105119684-105189837 (-)
CAST/EiJ	MGP_CASTEiJ_G0018635	protein coding gene	Chr11:112543874-112623686 (-)
CBA/J	MGP_CBAJ_G0019050	protein coding gene	Chr11:120974559-121059276 (-)
DBA/2J	MGP_DBA2J_G0019162	protein coding gene	Chr11:107367388-107442959 (-)
FVB/NJ	MGP_FVBNJ_G0019153	protein coding gene	Chr11:106857982-106930072 (-)
LP/J	MGP_LPJ_G0019232	protein coding gene	Chr11:113176605-113252863 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019184	protein coding gene	Chr11:120132606-120213436 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019759	protein coding gene	Chr11:111677727-111759399 (-)
PWK/PhJ	MGP_PWKPhJ_G0018400	protein coding gene	Chr11:108525868-108602707 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018190	protein coding gene	Chr11:111463104-111538359 (-)
WSB/EiJ	MGP_WSBEiJ_G0018686	protein coding gene	Chr11:111606650-111683807 (-)

Human Ortholog

RGS9, regulator of G protein signaling 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS9, regulator of G protein signaling 9
Synonyms

PERRS, PERRS1, RGS9L
Links

HGNC:10004

NCBI Gene ID: 8787

neXtProt AC: NX_O75916

UniProt: O75916
Chr Location

17q24.1; chr17:65100812-65227703 (+) GRCh38

MGI Vertebrate Homology

Rgs9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS9
Gene Tree

Rgs9

Diseases

1 with human RGS9 associations

				Human Disease	Mouse Models
				bradyopsia 1 IDs bradyopsia 1 DOID:0070363 OMIM:608415

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
18 phenotypes from multigenic genotypes
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

4
Transgenic

1
Incidental Mutations

APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a targeted null mutation are viable and fertile; however, relative to wild-type, homozygous null photoreceptors display abnormally retarded recovery of their light responses, and slowed rates of GTP hydrolysis by transducin.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

34
cDNA Data

55
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs9

ZFIN rgs9a, rgs9b

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS25576.1, CCDS48969.1

Ensembl

ENSMUSG00000020599 (Evidence)
NCBI Gene

19739

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020599	Ensembl Gene Model \| MGI Sequence Detail	72775	C57BL/6J	± kb
transcript	ENSMUST00000020920	Ensembl \| MGI Sequence Detail	2434	Not Applicable
polypeptide	ENSMUSP00000020920	Ensembl \| MGI Sequence Detail	675	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013965 regulator of G-protein signaling 9

(term hierarchy)
PDB

2PBI
InterPro Domains

IPR000591 DEP domain

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR047016 Regulator of G protein signaling 6/7/9/11

IPR047077 Regulator of G protein signaling 9, RGS domain

IPR047017 Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily

IPR040759 Regulator of G-protein signalling, DHEX domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

O54828 1 site, 1 O-linked glycan (1 site)

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All nucleic 58

cDNA 57

Primer pair 1

Microarray probesets 5

Summaries

All 97

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 55
Earliest

J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
Latest

J:352478 Pandey M, et al., Specific regulation of mechanical nociception by Gbeta5 involves GABA-B receptors. JCI Insight. 2023 Jul 10;8(13)

TSS for Rgs9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111531	Chr11:109188947-109188968 (-)	-3 bp
Tssr111530	Chr11:109188916-109188944 (-)	25 bp
Tssr111529	Chr11:109188898-109188905 (-)	53 bp
Tssr111528	Chr11:109180366-109180411 (-)	8,566 bp
Tssr111527	Chr11:109137786-109137803 (-)	51,160 bp
Tssr111526	Chr11:109137741-109137752 (-)	51,208 bp
Tssr111525	Chr11:109121991-109122001 (-)	66,959 bp
Tssr111524	Chr11:109121839-109121858 (-)	67,106 bp
Tssr3711	Chr11:109121793-109121797 (-)	67,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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