Il18rap MGI Mouse Gene Detail - MGI:1338888 - interleukin 18 receptor accessory protein

Symbol

Il18rap
Name

interleukin 18 receptor accessory protein
Synonyms

AcPL accessory protein-like)

Feature Type

protein coding gene
IDs

MGI:1338888
NCBI Gene: 16174
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:40554548-40590867 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 19.37 cM
Mapping Data

1 experiment

SNPs within 2kb

1202 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338888	protein coding gene	Chr1:40554522-40590867 (+)
129S1/SvImJ	ENSMUSG00200002523	protein coding gene	Chr1:38161066-38197420 (+)
A/J	ENSMUSG00195040452	protein coding gene	Chr1:37832837-37869158 (+)
AKR/J	ENSMUSG00220009169	protein coding gene	Chr1:37817833-37854164 (+)
BALB/cJ	ENSMUSG00180011446	protein coding gene	Chr1:37894127-37930474 (+)
C3H/HeJ	ENSMUSG00175001152	protein coding gene	Chr1:37835789-37872109 (+)
C57BL/6NJ	ENSMUSG00215017576	protein coding gene	Chr1:37869252-37905598 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014082	protein coding gene	Chr1:35127870-35159264 (+)
CAST/EiJ	ENSTCUG00005002709	protein coding gene	Chr1:37921693-37957303 (+)
CBA/J	ENSMUSG00210005818	protein coding gene	Chr1:37630874-37667216 (+)
DBA/2J	ENSMUSG00185009667	protein coding gene	Chr1:38733115-38769482 (+)
FVB/NJ	ENSMUSG00205019838	protein coding gene	Chr1:37840646-37877009 (+)
JF1/MsJ	ENSUMUG00000014424	protein coding gene	Chr1:37937442-37973080 (+)
LP/J	ENSMUSG00230021106	protein coding gene	Chr1:38760853-38797080 (+)
NOD/ShiLtJ	ENSMUSG00190033555	protein coding gene	Chr1:37849935-37886294 (+)
NZO/HlLtJ	ENSMUSG00225000472	protein coding gene	Chr1:42022855-42058518 (+)
PWK/PhJ	ENSLUMG00010030887	protein coding gene	Chr1:37455434-37491049 (+)
SPRET/EiJ	ENSMSPG00010024254	protein coding gene	Chr1:38958243-38990154 (+)
WSB/EiJ	ENSIUOG00005036929	protein coding gene	Chr1:37766400-37802775 (+)

Human Ortholog

IL18RAP, interleukin 18 receptor accessory protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL18RAP, interleukin 18 receptor accessory protein
Synonyms

ACPL, CD218b, CDw218b, IL-18RAcP, IL18RB, IL-18R-beta, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL
Links

HGNC:5989

NCBI Gene ID: 8807

UniProt: O95256
Chr Location

2q12.1; chr2:102418570-102452567 (+) GRCh38

MGI Vertebrate Homology

Il18rap stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL18RAP
Gene Tree

Il18rap

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

7
Targeted

6
Genomic Mutations

1 involving Il18rap
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

600
Tissues

1
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il18rap

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All Sequences

51
RefSeq

10
UniProt

5
CCDS

CCDS14912.1

Ensembl

ENSMUSG00000026068 (Evidence)
NCBI Gene

16174

			Length	Strain/Species	Flank
genomic	16174	NCBI Gene Model \| MGI Sequence Detail	36320	C57BL/6J	± kb
transcript	NM_010553	RefSeq \| MGI Sequence Detail	4856	C57BL/6
polypeptide	Q9Z2B1	UniProt \| EBI \| MGI Sequence Detail	614	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001378 interleukin-18 receptor accessory protein

(term hierarchy)
EC

3.2.2.6
InterPro Domains

IPR041416 IL-1Ra-like, immunoglobulin domain

IPR003599 Immunoglobulin domain subtype

IPR013151 Immunoglobulin-like beta-sandwich domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR015621 Interleukin-1 receptor family

IPR004074 Interleukin-1 receptor type I/II

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
GlyGen

Q9Z2B1 4 sites

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All nucleic 7

Genomic 1

cDNA 4

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 15
Earliest

J:50863 Born TL, et al., Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 1998 Nov 6;273(45):29445-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Il18rap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6477	Chr1:40554537-40554591 (+)	16 bp
Tssr6478	Chr1:40554602-40554618 (+)	62 bp
Tssr6479	Chr1:40554631-40554643 (+)	89 bp
Tssr65	Chr1:40554655-40554662 (+)	111 bp
Tssr6480	Chr1:40568760-40568771 (+)	14,218 bp
Tssr6481	Chr1:40573685-40573694 (+)	19,142 bp
Tssr6482	Chr1:40582117-40582130 (+)	27,576 bp
Tssr6483	Chr1:40582144-40582151 (+)	27,600 bp
Tssr6484	Chr1:40582154-40582168 (+)	27,613 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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